The 2001 National Lacrosse League season began on December 21, 2000 and concluded with the championship game on April 27, 2001. The Philadelphia Wings won their 6th NLL championship, defeating the Toronto Rock 9-8 in Toronto. Philadelphia had now won twice as many championships as any other team in NLL history (the Buffalo Bandits had won three, and the Rock two). The Championship game was one of only two games (out of ten) the Rock lost at home during the 2001 season, and ended Toronto's bid for an unprecedented third straight Championship.
The NLL expanded its schedule from 12 games to 14 during this season.
x–Clinched playoff berth; c–Clinched playoff berth by crossing over to another division; y–Clinched division; z–Clinched best regular season record; GP–Games Played; W–Wins; L–Losses GB–Games back; PCT–Win percentage; Home–Record at Home; Road–Record on the Road; GF–Goals scored; GA–Goals allowed; Diff–Difference between goals scored and allowed