Click on any series score to link to that series' page.
Higher seed has home field advantage during Division Series and League Championship Series.
The National League Champion has home field advantage during the World Series as a result of the pre-2003 "alternating years" rule.
American League is seeded 1-3/2-4 as a result of the AL regular season champion (Seattle Mariners) and the AL wild card (Oakland Athletics) coming from the same division.
National League is seeded 1-3/2-4 as a result of the NL regular season champion (Houston Astros) and the NL wild card (St. Louis Cardinals) coming from the same division.
January 22 - World Series standout Tommie Agee dies of a cardiac arrest in Manhattan at the age of 58. As the New York Mets center fielder, the 1966 AL Rookie of the Year makes two memorable catches (saving possibly five runs) and hits a home run in a 5–0 Game Three victory over the Baltimore Orioles in the 1969 Fall Classic.
January 26 - Alex Rodriguez signs as a free agent with the Texas Rangers. The ten-year contract worth $252 million is the most lucrative contract in sports history. The deal is worth $63 million more than the second-richest baseball deal.
March 23 - A panel of veteran baseball writers, historians and executives selects a roster of the 100 Greatest Cleveland Indians Players, as part of the club's 100th Anniversary Celebration.
March 24 - One of Major League Baseball's more bizarre moments occurs in a Spring Training game between the San Francisco Giants and the Arizona Diamondbacks. Randy Johnson is on the mound and pitches as a bird flies between the mound and the plate. The ball hits the bird in an "explosion of feathers" that kills the bird. The official call is a "no pitch".
Hideo Nomo hurls a 3-0 no-hitter against the Baltimore Orioles in his Boston Red Sox debut. It is Nomo's second career no-hitter, making him the fourth pitcher in history to hurl one in both the NL and the AL. It is also the earliest no-hitter, by date, in major league history, as well as the first by a Red Sox pitcher since Dave Morehead's gem in 1965.
April 14 - A major league record is set as 11 one-run games are played, breaking the mark of 10 set in 1967. With a 1–0 win over the New York Mets, the Cincinnati Reds set the modern-day National League record with their 175th consecutive game without being shut out, breaking the mark of 174 set by the 1992-93 Philadelphia Phillies.
May 8 - Randy Johnson of the Arizona Diamondbacks records twenty strikeouts in a game against the Cincinnati Reds. While all strikeouts come before the end of the ninth inning, the game goes to extra innings, with the Diamondbacks winning. Johnson is the first left-handed pitcher to record 20 strikeouts in a game, and is the first to do so without winning the game.
Gary Sheffield of the Los Angeles Dodgers becomes the first player in major league history to win three 1-0 games in a season with a home run, when he solos to beat the Atlanta Braves 1-0. He also supplies the only scoring by homering on April 2 versus Milwaukee, and on May 7 against Florida.
May 25 - Hideo Nomo of the Boston Red Sox tosses a one-hitter and strikes out 14 in a 4-0 win over the Toronto Blue Jays. Nomo faces one batter over the minimum of 27, giving up a leadoff double in the fourth inning to Shannon Stewart. Previously, Nomo tosses a no-hit game on April 4 against the Orioles.
August 6 - At Fenway Park, Scott Hatteberg of the Boston Red Sox becomes the first player to hit into a triple play and hit a grand slam home run in the same game. In the fourth inning of the Red Sox' victory over the Texas Rangers, Hatteberg lines out to shortstop Alex Rodriguez, who then throws to second, where Randy Velarde steps on the base to double up Brian Daubach, then tags out Chris Stynes (who runs from first) for the third out. Two innings later, Hatteberg gets revenge by homering with Troy O'Leary, Daubach and Stynes on base ahead of him; the grand slam puts the Red Sox ahead for the final 10-7 score. 
August 26 - Sammy Sosa hit his 50th and 51st home runs to power the Chicago Cubs to a 6-1 victory over the St. Louis Cardinals. He joins Mark McGwire and Babe Ruth as the only major leaguers with four 50-homer seasons.
September 1 - Rafael Palmeiro of the Texas Rangers collects his 100th run batted in. He becomes only the fourth major league player with seven consecutive seasons with at least 35 home runs and 100 RBI. This is the eighth time in his career he has at least 100 RBI. He joins some elite company; Jimmie Foxx has nine such consecutive seasons., and Babe Ruth and Sammy Sosa also have seven.
September 11 - Due to terrorist attacks in New York, Washington, and Pennsylvania, all future MLB games are postponed until further notice.
September 12 - Minor League Baseball cancels the remainder of the 2001 playoff series. All leaders in their series are deemed champions, and those series which do not start or tie have had all teams participating named co-champions.
September 14 - Commissioner Bud Selig announces that baseball resumes playing on September 17, six days after the 9/11 attacks.
September 21 - In the first sporting event in New York City since the 9/11 Terrorist Attacks, Mike Piazza hits a dramatic 2 run home run in the 8th inning to give the Mets a 3-2 win over the Atlanta Braves. Before the game the 2 rival teams shake hands to show that America is a country united.
September 23 - Sammy Sosa hits three home runs again.
October 6 - Tony Gwynndoubles off of the Colorado Rockies' Gabe White. It is the 3,141st and final hit of his career. His career batting average of 0.338 is, at the time of his retirement, the eleventh highest since 1901. It is the second highest of any player to play since 1950 (Ted Williams' 0.344), It is also the highest of any player to play entirely in the last 40 years of the 20th century.
Barry Bonds extends his major-league record with his 73rd home run of the season. He finishes the year with a .863 slugging percentage to break Babe Ruth's all-time single-season record.
In a day of records, the Chicago Cubs lose to the Pittsburgh Pirates in their final game of the season, 4–3. They become the first team in major league history to not allow an opposing pitcher to throw a complete game against them all season. Sammy Sosa closes out 2001 with his 64th home run in his final at-bat of the game and sets a new franchise record with 98 extra base hits, one more than Hack Wilson (1930). Sosa also finishes with another franchise record of 425 total bases (the seventh best all-time total), two ahead of Wilson. His 160 RBI are the highest total in the NL since Chuck Klein posts 170 in 1930; Sosa's RBI total for the past four years also breaks Klein's four-year mark set in 1929-32. To finish out the record day, five Cubs pitchers combine for 12 strikeouts as the staff sets a major league record with 1,246 strikeouts. The New York Yankees do the same, setting an AL mark with 1,266 strikeouts.
November 1 - The New York Yankees pull off 2 incredible comebacks. With the Arizona Diamondbacks leading 3-1 with 2 outs in the 9th inning of Game 4 of the 2001 World Series, Tino Martinez hits a game tying 2 run home run. One inning later (at 12:04 ET) Derek Jeter hits a walk-off home run to win Game 4, while fans wave a banner which says "Mr. November". Later that night in Game 5, with the Yankees trailing 2-0 in the 9th inning with 2 outs, Scott Brosius hits a 2 run game tying home run to tie that game at 2. The Yankees win 3-2 and take a 3-2 series lead.
November 11 - Mark McGwire announces his retirement. His 583 career home runs place him fifth on the all-time list.
Albert Pujols, just one year after playing Class-A baseball, hits a .329 batting average with 37 home runs and 130 RBI and is named the National League Rookie of the Year by the BBWAA. The St. Louis Cardinals freshman sets NL rookie marks in RBI, total bases (360) and extra base hits (88), and falls one home run shy of tying the NL rookie record of 38 established by Frank Robinson in 1956 as a member of the Cincinnati Reds.
November 27 - The major league owners vote unanimously to extend baseball commissioner Bud Selig's contract through 2006.
November 30 - Major League Baseball's plan to contract by two teams next season is put into jeopardy by Minnesota courts. The state's Supreme Court refuses to grant the request for a speedy review of the appeal of the injunction which forces the Twins to play in 2001, and the appellate court sets the hearing for December 27, a date many believe is too late to make the elimination of two teams a reality. Unsure of their future, the Expos sign a one-year lease to play their home games of the 2002 season at Olympic Stadium. Due to the threat of being eliminated because of the proposed contraction, the agreement gives the Expos the right to unilaterally cancel the contract.
January 3 - Alex Sabo, 90, backup catcher for the Washington Senators in the 1936 and 1937 seasons.
January 6 - Tom Poholsky, 71, pitcher for the St. Louis Cardinals and Chicago Cubs between 1950 and 1957.
January 6 - Tot Pressnell, 94, who pitched from 1938 through 1942 for the Brooklyn Dodgers and Chicago Cubs.
January 8 - Bert Hodges, 83, third baseman for the 1942 Philadelphia Phillies.
January 14 - Joe Zapustas, 93, backup outfielder for the 1933 Philadelphia Athletics.
January 19 - Johnny Babich, 87, pitcher for the Brooklyn Dodgers, Boston Bees and Philadelphia Athletics between 1934 and 1941.
January 22 - Tommie Agee, 58, All-Star center fielder who was the 1966 AL Rookie of the Year with the Chicago White Sox, best remembered for two outstanding catches in Game 3 of the 1969 World Series that helped the New York Mets win the world championship.
January 28 - Curt Blefary, 57, outfielder who earned the 1965 AL Rookie of the Year Award with the Baltimore Orioles.
February 1 - Sam Harshaney, 90, backup catcher for the St. Louis Browns from 1937 to 1940.
February 5 - Jerry McQuaig, 89, outfielder for the 1934 Philadelphia Athletics.
February 16 - Bob Buhl, 72, All-Star pitcher for the Milwaukee Braves, Chicago Cubs and Philadelphia Phillies from 1953 to 1967, who posted a 166-133 record and a 3.52 ERA in 457 games, while leading NL pitchers with a .720 winning percentage in 1957.
February 18 - Eddie Mathews, 69, Hall of Fame third baseman for the Braves in Boston, Milwaukee and Atlanta, who retired with 512 home runs, sixth most in history, hitting 40 homers four times and leading NL twice; batted .300 three times, scored 100 runs eight times and had five 100-RBI seasons. A fine defensive player, he set major league records with 2181 games and 4323 assists at third base, setting a NL mark with 369 double plays. He also appeared on first cover of Sports Illustrated in 1954, was manager of the Braves in 1974 when former teammate Hank Aaron broke all-time career home run record.
February 18 - Butch Wensloff, 85, pitcher for the 1943-1947 New York Yankees and the 1948 Cleveland Indians.
February 20 - Bill Rigney, 83, manager of the Giants when team moved to San Francisco, later managed Angels, and led Twins to 1970 division title; previously an All-Star infielder for Giants in New York.
February 24 - Phil Collier, 75, sportswriter for the San Diego Union-Tribune who covered the Dodgers, Angels and Padres from 1958 to 1999.
February 25 - Bitsy Mott, 82, backup infielder for the 1946 Philadelphia Phillies, who also worked later as the personal security guard for rock-and-roll star Elvis Presley.
April 9 - Willie Stargell, 61, Hall of Fame left fielder for the Pittsburgh Pirates who hit 475 home runs, leading NL twice; was MVP of the regular season, NLCS and World Series in 1979, the only player to do so; batted .300 three times and had five 100-RBI seasons
April 16 - Hank Riebe, 79, catcher for the Detroit Tigers in the 1940s, and a highly decorated World War II veteran
April 21 - Sandy Ullrich, 79, Cuban pitcher for the Washington Senators from 1944 to 1945
April 21 - Hal White, 82, pitcher for the Tigers who eaned shutouts in his first two major league starts; later a coach and scout
May 19 - Joe Lovitto, 50, the Texas Rangers' first center fielder, from 1972–75
May 21 - Mel Hoderlein, 77, utility infielder for the Boston Red Sox and Washington Senators in the 1950s
July 17 - Chief Hogsett, 97, pitcher for the Tigers who made a critical relief appearance in the 1935 World Series
August 10 - Lou Boudreau, 84, Hall of Fame shortstop for the Cleveland Indians who won 1948 MVP award after leading team to World Series title as a player-manager, the last person to do so; won 1944 batting title and led AL in doubles three times, later a broadcaster
August 24 - Hank Sauer, 84, All-Star left fielder for four NL teams after rookie season at age 31; won 1952 MVP award with the Cubs after leading league in home runs and RBI
August 29 - Dick Selma, 57, pitcher who won the San Diego Padres' first game in 1969 and saved 22 games for 1970 Phillies
September 11 - Clem Dreisewerd, 85, pitcher for the Boston Red Sox, St. Louis Browns and New York Giants between 1944 and 1948, who also enjoyed a long and successfully minor league career
September 17 - Bubba Church, 77, pitcher who won 15 games for 1951 Phillies, also played for the Reds and Cubs
September 19 - Bill Stafford, 62, In 1961, Stafford had the second best ERA in the American League with 2.68. On October 1 of that season, he was the winning pitcher when Roger Maris hit his 61st home run of the season, breaking Babe Ruth's single-season record of 60 in 1927.
September 20 - Joe Stephenson, 80, backup catcher for three teams who gained renown as a scout for the Red Sox
September 25 - Ritter Collett, 80, sportswriter who covered the Cincinnati Reds for various Dayton newspapers since 1946
October 5 - Woody Jensen, 94, left fielder for the Pirates who batted .324 in 1935 and set a record with 696 at bats in 1936
October 18 - Ferris Fain, 80, five-time All-Star first baseman for the Athletics and White Sox who won consecutive batting titles in 1951-52
October 19 - Joe Murray, 80, pitcher for the 1950 Philadelphia Athletics
November 4 - Bob Gillespie, 82, pitcher for the Detroit Tigers, Chicago White Sox and Boston Red Sox between 1944 and 1950
November 16 - Red Steiner, 86, catcher for the Cleveland Indians and Boston Red Sox during the 1945 season
November 18 - Mel Deutsch, 86, pitched for the 1946 Boston Red Sox
November 23 - Bo Belinsky, 64, pitcher who enjoyed a 10-win rookie season in 1962 with the Angels, including the first no-hitter on the West Coast, but whose raucous personal life derailed his career
November 29 - Marcelino López, 58, Cuban pitcher who won 14 games as a 1965 rookie with the Angels but never recaptured the same form
December 21 - Karl Winsch, 86, Philadelphia Phillies minor league pitcher and a successful manager in the AAGPBL
December 24 - Hank Soar, 87, American League umpire from 1950 to 1971 who worked in five World Series and the 1971 ALCS before becoming a league supervisor; former football player with the New York Giants
December 25 - Ramón García, 77, Cuban pitcher for the 1948 Washington Senators
December 26 - Tom McBride, 87, outfielder who batted .305 for the 1945 Red Sox, getting six RBI in one inning in August