Marshall started the scoring with a 9-yard touchdown pass from Byron Leftwich to wide receiver Denero Marriott for a 7-0 lead.In the second quarter, Marshall's Curtis Head kicked a 23-yard field goal to give Marshall a 10-0 lead. Byron Leftwich later tossed an 8-yard touchdown pass to wide receiver Demetrius Doss for a 17-0 lead. Louisville got on the board with a 2 yard TJ Patterson touchdown run, making the score 17-7.
In the third quarter, Byron Leftwich again connected with Demetrius Doss for a 12-yard touchdown pass and a 24-7 lead. He later found Denero Marriott for a 26-yard touchdown pass in the fourth quarter. Franklin Wallace added a 15-yard touchdown run to give Marshall a 38-7 lead. With 13 seconds left in the game, quarterback Dave Ragone found Tiger Jones in the end zone for a Louisville touchdown. The two-point conversion to Jones made the final score 38-15.