September 8: The Seahawks began their new life as an NFC team with an interconference run through their old division, the AFC West. At Oakland Matt Hasselbeck threw for 155 yards and two touchdowns but Rich Gannon threw for 214 yards and two scores while he and four Raiders backs combined for 221 rushing yards and two touchdowns in a 31-17 Raiders win.
September 15: The Seahawks opened their new stadium by being outscored 14-3 in the fourth quarter, losing 24-13 to the Cardinals. Trent Dilfer started instead of Hasselback and threw for 352 yards but managed one touchdown.
September 22: The Seahawks traveled to Giants Stadium and lost a 9-6 battle of field goals to the Giants. The Hawks managed just 145 yards of offense.
September 29: The Seahawks finally got on the victory board by crushing the Vikings 48-23. The two teams combined for 353 rushing yards and seven touchdowns, while the Seahawks won the turnover battle, forcing two fumbles while picking off Daunte Culpepper twice.
October 20: The Seahawks traveled to St. Louis and fell to 1-5 after Marshall Faulk erupted to four touchdowns, three of them on the ground as the Rams won 37-20. Trent Dilfer was intercepted twice.
October 27: Against the Seahawks, Cowboys running back Emmitt Smith surpassed Walter Payton as the NFL’s All-Time Leading Rusher. This game also marked the team's full-time switch at starting quarterback; starter Trent Dilfer was injured after compiling just 46 passing yards; backup Matt Hasselbeck replaced Dilfer and became starter the next week.