The 2005 French Open was the 104th edition of the tournament. Rafael Nadal, seeded fourth at his first French Open (but was actually ranked World No. 5 at the time after then-World No. 2 Lleyton Hewitt withdrew from the tournament due to injury), was a strong favorite after winning the Rome and Monte Carlo Masters, with Guillermo Coria, a 2004 finalist and runner-up in Monaco, calling Nadal the best clay-court player in the world prior to the tournament. After defeating top seed Roger Federer in the semi-finals, Nadal defeated Argentina's Mariano Puerta to claim his first French Open titles, and the first of four won consecutively from 2005 until 2008.
Gastón Gaudio and Anastasia Myskina were unsuccessful in defending their 2004 titles, Gaudio losing in the fourth round and Myskina being upset in the first round. This tournament was also notable for the rise of future French Open champion Ana Ivanovic, who upset the 3rd seed Amélie Mauresmo in the third round, before going on to defeat another future champion in Francesca Schiavone on her way to her first Grand Slam quarter-final appearance in what was just her second Grand Slam tournament.
^Henin-Hardenne became only the second French Open women's singles winner after saving match points en route to the title. In 2004 Myskina did the same.
Both saved match points against Russian Svetlana Kuznetsova in the fourth round.