The Packers opened the 2005 NFL season with a loss to the Detroit Lions. Starting wide receiver Javon Walker injured his right knee and did not play the rest of the season. This would be the Lions last win over the Packers until the 2010 season.
The Packers lost this game to the Cleveland Browns as quarterback Trent Dilfer threw for 336 yards. The Packers retired the great Reggie White's number 92 at halftime after his unexpected death in December 2004.
The Carolina Panthers caused the worst start in 17 years for the Packers as they could not complete a fourth quarter comeback to win the game. The Packers lost promising rookie Terrence Murphy in a career-ending helmet to helmet collision on a kickoff return.
After starting the season 0–4, the Packers defeat the New Orleans Saints in this blowout. Running back Najeh Davenport ended his season with an ankle injury in the second quarter. This was the largest blowout in Brett Favre's career.
The Minnesota Vikings scored 23 second half points after being shut out 17–0 in the first half. Paul Edinger kicked a career long 56-yard field goal as time ran out to win the game. Packers running back Ahman Green ended his season with a career-threatening knee injury.
Brett Favre threw five interceptions as the Cincinnati Bengals won this close game. It is also noteworthy for the fact that a fan ran onto the field in the closing moments of the 4th quarter and disrupted the game by taking the ball away from Favre.
The Pittsburgh Steelers, who were held without a third down conversion, forced three turnovers that turned into 17 points to help them defeat the Packers. Packers running back Samkon Gado scored his first career touchdown and ended the day with 62 yards.
On his 24th birthday, running back Samkon Gado makes has first career start against the Atlanta Falcons and finishes the day with 103 yards and three touchdowns to help the Packers win their second game of the year.
The Packers win their last game of the season over the Seattle Seahawks. Packer fans gave Brett Favre a standing ovation at the beginning and end of the game as it was possibly his last game, which turned out not to be the case.