In the first inning, starters Mark Buehrle and Chris Carpenter each induced a double play, from Carlos Beltran and Manny Ramírez respectively, to end early threats. The American League would score in the bottom of the second, when the game's MVP, Miguel Tejada, crushed a solo shot off John Smoltz to give the AL a 1-0 lead. The AL would score two more in the third, on the strength of a David OrtizRBI single, and an RBI groundout by Tejada, his second RBI in as many innings.
The NL wasted a scoring opportunity in the top of the fourth, when with two runners on, Aramis Ramirez grounded into a double play to end that threat. In the bottom of that inning, Ichiro Suzuki hit a broken-bat, bloop single to score two, but was then picked off first base by Liván Hernández. Then, in the bottom of the sixth, Mark Teixeira, a switch-hitter, hit an opposite field, two-run homer off Dontrelle Willis, his first home run off a left-hander that season, opening the AL's lead to 7-0.
The NL finally got on the board in the next inning, when Andruw Jones launched a two-run shot just inside the foul pole off Kenny Rogers to close the NL to within five. They scored another run in the eighth, when Moisés Alou scored on an RBI forceout by Miguel Cabrera.
In the top of the ninth, Luis Gonzalez scored Andruw Jones with a double off of Baltimore closer B.J. Ryan, and then scored himself on an RBI groundout by Carlos Lee. Mariano Rivera then came on to stop the NL's potential rally. Rivera struck out Morgan Ensberg to end the threat, and the game, securing a 7-5 win for the AL.
In this event, the eight competitors each came from a different nation. This format dovetailed with the announcement of the launch of the World Baseball Classic the week before, as of the following year.