The 2006–07 Mercyhurst Lakers women's ice hockey team represented Mercyhurst College in the 2006–07 NCAA Division I women's ice hockey season. The Lakers were coached by Michael Sisti and went 11-0-1 in their conference. Mercyhurst had the second-best scoring defense in Division I in 2006-2007. It would be the rookie season of Meghan Agosta. She was the first freshman ever to be in the Final 3 for the Patty Kazmaier Award. No other freshman had made it that far in voting.
The Lakers made local, regional and national headlines (features in the USA Today and New York Times). In late November, the Lakers were ranked #1 and stayed there for 11 consecutive weeks. In addition, the Lakers accumulated a 24 game unbeaten streak to finish the season (twenty two wins and two losses).
October 28: Against the Providence Friars women's ice hockey program, Jill Nugent scored her only goal of the season. The Lakers prevailed 4-3. Danielle Ayearst scored the unassisted game-winning goal.
Stephanie Bourbeau appeared in all 37 games. Statistically, Bourbeau’s 5 game-winning goals were tied for 13th nationally. Her 8 power play goals were tied for 17th. Bourbeau finished the season tied for first all-time in Lakers career points with 130 and finished first in career goals with 67 (both marks since broken). In the CHA, she tied for first in shorthanded goals, and tied for 2nd in game-winning goals. In addition, she was 3d in the CHA in points, tied for 3rd in power play goals, 4th in assists, and tied for 4th in goals.
Laura Hosier appeared in 32 games and managed seven shutouts. Hosier’s 27 wins set a new one-season mark for her career. Nationally, Laura Hosier ranked 2nd in winning percentage (.903), 4th in goals-against-average (1.52), and 10th in save percentage (.921). After losing to the St. Lawrence Saints on November 18, Hosier went 17-1-2 the rest of the season. Her conference record was 8-0-1.
Jackie Jarrell rejoined the team after a year and-a-half absence due to injury. She played in 31 games, and other than goaltender Laura Hosier, had fewest penalties on team (2 for 4).
Stephanie Jones played in 35 games and tied for 20th nationally by scoring four game-winning goals. In the CHA, she ranked 8th in points, while tying for fourth in goals, and tying for ninth in assists.
In addition to playing for the Lakers, Meghan Agosta was a member of Canada’s Under-22 Team at the 2007 European Air Canada Cup. She was also selected to play for Team Canada at Women’s World Championship in Winnipeg, Alberta. She had a four-goal and five-point game (season bests) against Yale on January 26, and scored a hat trick against Connecticut on January 20. She had at least one point in 31 of 35 games played and had 23 multiple point games and nine multiple-goal games. In addition, she set team one-season marks for goals (38), points (74), game-winning goals (11), and shorthanded goals (6). She was first nationally in goals-per-game (1.09), game-winning goals (11), and points-per-game by a rookie (2.11)
Valerie Chouinard ranked first nationally in power play goals with 17. For the season, Chouinard played in 35 games and ranked second on the team in goals, third in assists, and second in points. With her 17 power play goals, she moved into first place on Mercyhurst’s all-timelist with 24. She had at least one point in 26 games, highlighted by a seven game point scoring streak. In the CHA, Chouinard ranked second in points, and goals.
Julia Colizza finished her Lakers career by never missing a game in her career. In addition, she was the team captain. She finished her career third all-time at Mercyhurst in points (126) and second all-time in assists (79). In her final season, she tied for first in the CHA in assists, 4th in points (tied), and 5th in power play goals (tied).
Ashley Pendleton played in all 37 games during the season. In addition, she never missed a contest in her career. As one of the seniors on the team, she finished with 147 games played (25 goals, 53 assists, 78 points). In team scoring, she ranked second among defenders (she led defenders in goals) 
Mercyhurst hosted its first-ever Division I NCAA playoff game on March 9, 2007, and, for the third straight year, lost in the quarterfinals, this time to Minnesota Duluth 3-2 in overtime. Once again, the Lakers never trailed until the final horn.