Running back Tony Temple started the scoring for Missouri as he took a handoff and ran 7 yards for a touchdown, to give Missouri an early 7-0 lead. Quarterback Matt Moore threw a 13-yard touchdown pass to wide receiver Sammie Stroughter to tie the game at 7. Matt Moore later ran for a 1-yard touchdown to increase the lead to 14-7.
Missouri placekicker Jeff Wolfert kicked a 30-yard field goal to cut the lead to 14-10. Quarterback Chase Daniel threw a 74-yard touchdown pass to wide receiver Danario Alexander, to give the lead to Missouri, 17-14.
In the third quarter, Matt Moore found all Pac-10 tight end Joe Newton for an 11-yard touchdown pass and a 21-17 Oregon State lead. Tight end Chase Coffman took a handoff, but then threw to a streaking Tommy Saunders for a 29-yard touchdown to give Missouri a 24-21 lead. Tony Temple later broke free on a 65-yard touchdown run to stretch the lead to 31-21.
Oregon State kicker Alexis Serna drilled a 29-yard field goal to cut the lead to 31-24. With 12:08 left in the game, Chase Daniel found Chase Coffman in the end zone for an 18-yard touchdown, stretching the lead to 38-24. With 6:02 left in the game, Matt Moore threw a 7-yard touchdown pass to running back Yvenson Bernard, to trim the lead to 38-31. Moore later fired a 14-yard touchdown pass to Joe Newton with only 23 seconds left to make it 38-37. Yvenson Bernard plowed ahead on the two-point conversion attempt, and Oregon State won 39-38.