The 2008 Major League Baseball First-Year Player Draft continued Major League Baseball's annual amateur draft of high school and college baseball players, and was held on June 5 and 6, 2008.
First round selections
Supplemental first round selections
Other notable players
- Robbie Ross, 2nd round, 57th overall by the Texas Rangers
- Tyson Ross, 2nd round, 58th overall by the Oakland Athletics
- Josh Lindblom, 2nd round, 61st overall by the Los Angeles Dodgers
- Bryan Shaw, 2nd round, 73rd overall by the Arizona Diamondbacks
- Tyler Chatwood, 2nd round, 74th overall by the Los Angeles Angels of Anaheim
- Stephen Fife, 3rd round, 85th overall by the Boston Red Sox
- Danny Espinosa, 3rd round, 87th overall by the Washington Nationals
- Craig Kimbrel, 3rd round, 96th overall by the Atlanta Braves
- Vance Worley, 3rd round, 102nd overall by the Philadelphia Phillies
- Brandon Crawford, 4th round, 117th overall by the San Francisco Giants
- Dee Gordon, 4th round, 127th overall by the Los Angeles Dodgers
- Jason Kipnis, 4th round, 135th overall by the San Diego Padres, but did not sign
- Daniel Hudson, 5th round, 150th overall by the Chicago White Sox
- Alex Avila, 5th round, 163rd overall by the Detroit Tigers
- Anthony Bass, 5th round, 165th overall by the San Diego Padres
- Ryan Westmoreland, 5th round, 172nd overall by the Boston Red Sox
- Eric Thames, 7th round, 219th overall by the Toronto Blue Jays
- Andy Dirks, 8th round, 253rd overall by the Detroit Tigers
- Tommy Milone, 10th round, 301st overall by the Washington Nationals
- J. J. Hoover, 10th round, 310th overall by the Atlanta Braves
- Nathan Eovaldi, 11th round, 337th overall by the Los Angeles Dodgers
- Tony Campana, 13th round, 401st overall by the Chicago Cubs
- David Phelps, 14th round, 440th overall by the New York Yankees
- Tom Koehler, 18th round, 538th overall by the Florida Marlins
- Nick Vincent, 18th round, 555th overall by the San Diego Padres
- Lucas Luetge, 21st round, 638th overall by the Milwaukee Brewers
- Anthony Rendon, 27th round, 820th overall by the Atlanta Braves, but did not sign
- Ryan Cook, 27th round, 828th overall by the Arizona Diamondbacks
- Yan Gomes, 39th round, 1,192nd overall by the Boston Red Sox, but did not sign
NFL players drafted
- Kyle Long, 23rd round, 690th overall by the Chicago White Sox, but did not sign
- Eric Decker, 39th round, 1,178th overall by the Milwaukee Brewers, but did not sign
- Pat White, 49th round, 1,457th overall by the Cincinnati Reds, but did not sign
On September 9, 2008, Conor Gillaspie, the 37th pick in the 2008 draft, made his Major League debut, becoming the first from his draft class to do so. Buster Posey was the first in the 2008 Draftee to play in post-season and eventually won the 2010 World Series and the 2012 World Series with the San Francisco Giants. Posey was also named 2010 NL Rookie of the Year, and he won 2012 National League Most Valuable Player award.
2011 Rookie of the Year Craig Kimbrel was drafted 96th overall by the Atlanta Braves in the 3rd round.
Ryan Westmoreland, who the Boston Red Sox drafted in the fifth round, became one of the best prospects in baseball before having brain surgery twice to repair a cavernous malformation.
Brothers Caleb and Corban Joseph were both chosen in the 2008 draft. The New York Yankees selected Corban in the fourth round, with the 140th overall selection, out of Franklin High School in Franklin, Tennessee, while the Baltimore Orioles drafted Caleb in the seventh round, with the 206th overall selection, out of Lipscomb University.
West Virginia quarterback Pat White was drafted in the 49th round by the Cincinnati Reds, even though he had not played baseball since his senior year of high school in 2004, when he was drafted by the Anaheim Angels.