Nevada finished the regular season with a 7–5 mark, 5–3 in WAC play, which resulted in a three-way tie for second-place in the conference. Hawaii and Louisiana Tech both likewise finished with 5–3 conference records. During the season, the Wolf Pack played three ranked teams: Texas Tech, Missouri, and Boise State. Nevada lost each game, but gave Boise State its closest contest in conference play, losing by seven points. Nevada, however, suffered a setback when they lost to New Mexico State, who were called by one publication the "perennial WAC bottom feeders".
Quarterback Colin Kaepernick was named 2008 WAC Offensive Player of the Year. During the regular season, he passed for 2,479 yards and 19 touchdowns and rushed for 1,115 yards and 16 touchdowns. He was aided by running back Vai Taua, who ran for 1,420 yards and 14 touchdowns. It was the first time in school history that Nevada had two 1,000 yard rushers on the team simultaneously.