In the opening game of the 2008 season, the Cowboys would down the Ohio Bobcats at home 21-20. In the first quarter, Ohio would score first on a 4-yard Theo Scott touchdown pass to Andrew Mooney, only to have to Cowboys answer with a 6-yard Devin Moore touchdown run to knot the game at 7-7 entering the second quarter. In the second, Wyoming would open the scoring with a 3-yard Dax Crum touchdown pass to J. Salyards and take a 14-7 lead. The Bobcats would answer with 10 consecutive points on a 100-yard Donte Harden kickoff return, and a 31-yard Barrett Way field goal in taking a 17-14 halftime lead. After a scoreless third, Ohio would extend its lead to 20-14 after converting a 34-yard Way field goal. The Cowboys would respond with what turned out to be the game-winning touchdown midway through the fourth on a 23-yard Crum touchdown pass to Donate Morgan to win by a final score of 21-20.
In the Mountain West opener, the Cowboys would surrender 20 unanswered, second half points in this 23-3 loss to the Falcons. After a scoreless first, the Cowboys would respond to an Air Force field goal with a 47-yard Jake Scott field goal late in the second to tie the game at 3-3 going into the half for their only points on the afternoon.
After falling behind in the third quarter by a score of 13-0 to the FCS Bison, the Cowboys would rally back with 16 unanswered points in taking a 16-13 victory at home. Midway through the third, the Cowboys would score their first points on a 2-yard Devin Moore touchdown run to close the gap to 13-7. Kicker Jake Scott would then provide the remainder of scoring on a pair of 28-yard field goals, and a third from 29-yards with only :04 seconds remaining in the contest to take the win.