The 2009–10 Second Macedonian Football League was the eighteenth season since its establishment. It began on 15 August 2009 and ended on 19 May 2010. Due to the expansion of the league, no teams were relegated this season.
Updated to games played on 19 May 2010.
Rules for classification: 1st points; 2nd goal difference; 3rd goals scored; 4th head-to-head points; 5th head-to-head goal difference; 6th head-to-head goals scored; 7th draw.
For deciding promotion, relegation and promotion/relegation play-offs: 1st points; 2nd head-to-head points; 3rd head-to-head goal difference; 4th head-to-head goals scored; 5th play-off. 1Škendija 79 were deducted 6 points for unpaid obligations to three Senegalese players 2Ohrid were deducted 3 points (C) = Champion; (R) = Relegated; (P) = Promoted; (E) = Eliminated; (O) = Play-off winner; (A) = Advances to a further round.
Only applicable when the season is not finished: (Q) = Qualified to the phase of tournament indicated; (TQ) = Qualified to tournament, but not yet to the particular phase indicated; (RQ) = Qualified to the relegation tournament indicated; (DQ) = Disqualified from tournament.
Head-to-Head: used when head-to-head record is used to rank tied teams.