The 2010–11 Slovenian Cup was the 20th season of Slovenia's football knockout competition. Maribor were the defending champions, having won their sixth Slovenian Cup last season.
Celje, Domžale, Drava Ptuj, Gorica, Interblock, Koper, Maribor, Nafta Lendava, Olimpija, Rudar Velenje
MNZ Ljubljana: Krka, Dob
MNZ Maribor: Dogoše, Malečnik
MNZ Celje: Dravinja, Krško
MNZ Koper: Postojna, Ankaran
MNZ Nova Gorica: Primorje, Brda
MNZ Murska Sobota: Mura 05, Tromejnik
MNZ Lendava: Hotiza, Bistrica
MNZ Kranj: Triglav Kranj, Šenčur
MNZ Ptuj: Aluminij, Zavrč
These matches took place on 24 and 25 August 2010.
Gorica, Koper, Maribor and Olimpija received byes to this round. These matches took place on 14, 15 and 29 September 2010.
The first legs took place on 20 October 2010 and the second legs took place on 27 October and 3 November 2010.
The four winners from the previous round competed in this round. The first legs took place on 20 April 2011 and the second legs took place on 26 April 2011.