The 2010 Armenian Independence Cup was the 19th season of Armenian knockout football competition. It featured only the 8 Premier League teams. The tournament started on 23 March 2010. Pyunik won their second consecutive Armenian Cup with a 4–0 victory over Banants in the final. Because Pyunik qualified for the 2010–11 UEFA Champions League as league champions, Banants claimed the cup winner berth in the 2010–11 UEFA Europa League.
The eight clubs in this year's Armenian Premier League compete in this round. The first legs were played on 23 and 24 March 2010 and the second legs were played on 6 and 7 April 2010.
The four winners from the Quarterfinals enter this round. The first legs were played on 13 and 14 April 2010 and the second legs were played on 20 and 21 April 2010