Theoretically, up to 55 CAF member associations entered the 2010 CAF Champions League.
The 12 highest ranked associations according to CAF 5-Year Ranking were eligible to enter 2 teams in the competition. For this year's competition, CAF used 2004-08 5-Year ranking. As a result, a maximum of 67 teams entered the tournament - although this level has never been reached.
Below is the qualification scheme for the competition. Nations are shown according to their CAF 5-Year Ranking - those with a ranking score have their rank and score indicated:
Unranked associations have no ranking points and hence are equal 20th. Bolded clubs received a bye in the preliminary round, entering the tournament in the first round.
TH Title holders 1Hearts of Oak, the champion of Ghana, did not enter the competition, citing financial problems. 2 A position was included for a representative of the association at the time of the draw, but the association eventually withdrew without sending a team.