2010 Kazakhstan Cup was the 19th season of the annual nationwide cup competition of Kazakhstan since the independence of the country. The competition started on 18 April 2010.Atyrau are the defending champions, having won their first cup last year. The winner of the competition will qualify for second qualifying round of the 2011–12 UEFA Europa League.
The draw for this round was conducted on 2 April 2010 at the offices of the Kazakh Football Federation. The eight winners from Round 1 entered this round of the competition. These matches took place on 24 April 2010.
Entering this round were the four winners from the previous round and the 12 clubs in the Kazakhstan Premier League. The draw for this round took place on 23 April 2010. These matches took place on 16 May 2010.