28S ribosomal RNA

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16S and 28S phylogenies of three Waldo species

28S ribosomal RNA is the eukaryotic nuclear homologue of the prokaryotic [invalid/archaic clade] 23S ribosomal RNA. This is the structural RNA for the large component of eukaryotic cytoplasmic ribosomes, and thus one of the basic components of all eukaryotic cells.[1]

The genes coding for 28S rRNA are referred to as 28S rDNA. Sequences from these genes are sometimes used in molecular analysis to construct phylogenetic trees.[2]


  1. ^ Lodish, H. (1995). Molecular Cell Biology, 3rd ed. Freeman.
  2. ^ Mallatt, Jon; Sullivan, Jack (December 1998). "28S and 18S rDNA sequences support the monophyly of lampreys and hagfishes". Molecular Biology and Evolution 15 (12): 1706–18. doi:10.1093/oxfordjournals.molbev.a025897. PMID 9866205.