|This article relies too much on references to primary sources. (January 2012)|
|Jmol-3D images||Image 1|
|Molar mass||241.35 g/mol|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
2C-T-2, or 2,5-dimethoxy-4-ethylthiophenethylamine is a psychedelic and entactogenic phenethylamine of the 2C family. It was first synthesized in 1981 by Alexander Shulgin. The drug has structural and pharmacodynamic properties similar to the drug 2C-T-7 ('Blue Mystic').
In Alexander Shulgin's book PiHKAL, the dosage range is listed as 12 to 25 mg. According to Erowid a threshold dose would be 5 mg, a light dose would range from 8–15 mg, a common dose is 15–22 mg and a strong dose would be considered to be 20–40 mg.
Effects are similar to the related 2C-T-7, but 2C-T-2 is said to produce more of a body load and other reactions which can be unpleasant, reported effects being reddening of the face and warm flushes. It can also be very nauseating while coming up, some users report a period of restlessness during the come up and feeling cold. There have been no reported deaths from 2C-T-2, unlike 2C-T-7, and the psychedelic effects have been much milder. The onset usually starts after an hour of ingestion and rises for about 2 hours until the user hits the plateau. Insufflated doses reach a peak much faster and have been compared to the effect of ketamine on the body .
Hallucinations similar to those created by LSD and other serotonergic psychedelics are very prominent on typical 2C-T-2 doses. The trip is often described as being similar to LSD due to the serotonergic effects and hallucinations. Some users describe "beautiful" visuals, similar to 2C-T-7 which has coined its street name "Rosy". In some aspects the effect is similar to other phenethylamines like MDMA (users sometimes have euphoric rushes); however, unlike MDMA, 2C-T-2 is a strong psychedelic, and its effects can be unpredictable, even for "experienced" users.
2C-T-2 can be just as powerful as LSD and other hallucinogens. Due to the particular body load effect of this substance it is significantly different than most popular hallucinogens though its capability to produce a bad trip is still present.
There are no known reports of neurotoxicity. Currently, 2C-T-2 is a research chemical. It is commonly assumed that the drug meets the same "level" of safety that 2C-B would because it is within the 2C class of phenethylamines though this is a misconception; all research chemicals are a potential risk to the user. Very little scientific knowledge exists for 2C-T-2, unlike 2C-B. Effects can last up to 16 hours from dosing.
The mechanism of action that produces 2C-T-2’s hallucinogenic and entheogenic effects has not been specifically established, however it is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines for which the mechanism of action is known.
The toxicity of 2C-T-2 is not well documented, but it may be expected that at higher doses it would display similar toxicity to that of other phenethylamines of the 2C-T family. Other phenethylamine derivatives substituted with an alkylthio group at the 4 position such as 2C-T-7 and 4-MTA are known to act as selective monoamine oxidase A inhibitors, a side effect which can lead to lethal serotonin syndrome when combined with stimulant drugs . Most confirmed fatalities involving 2C-T drugs involve their combination with other drugs such as alcohol, MDMA (ecstasy) or cocaine. It is also dangerous for a person who takes certain kinds of medication, OTC or prescription, to ingest 2C-T-2 . Unfortunately not much is known about contraindications.
Drug prohibition laws
The Netherlands became the first country in the world to ban 2C-T-2, and classify it as a hard drug, by law. In April, 1999, 2C-T-2 became a list I drug of the Opium Law.
Schedule I in Sweden. 2C-T-2 was first classified as "health hazard" under the act Lagen om förbud mot vissa hälsofarliga varor (translated Act on the Prohibition of Certain Goods Dangerous to Health) as of April 1, 1999 under SFS 1999:58 that made it illegal to sell or possess.
2C-T-2 is specifically listed as a schedule I substance under SEC. 1152 of S.3187: Food and Drug Administration Safety and Innovation Act of 2012.
- Theobald, DS; R Staack; M Puetz; HH Mauer (September 2005). "New designer drug 2,5-dimethoxy-4-ethylthio-β-phenethylamine (2C-T-2): studies on its metabolism and toxicological detection in rat urine using gas chromatography/mass spectrometry". Journal of Mass Spectrometry 40 (9): 1157–1172. doi:10.1002/jms.890. PMID 16041763.
- Last Argentina Controlled Drugs List
- PiHKAL #40 2C-T-2
- 2C-T-2 entry in PiHKAL • info
- 2C-T-2 vault at Erowid
- Sulfurous Samadhi: An Investigation of 2C-T-2 & 2C-T-7