3',5'-cyclic-AMP phosphodiesterase

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3',5'-cyclic-AMP phosphodiesterase
Identifiers
EC number 3.1.4.53
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

3',5'-cyclic-AMP phosphodiesterase (EC 3.1.4.53, cAMP-specific phosphodiesterase, cAMP-specific PDE, PDE1, PDE2A, PDE2B, PDE4, PDE7, PDE8, PDEB1, PDEB2) is an enzyme with system name 3',5'-cyclic-AMP 5'-nucleotidohydrolase.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction

adenosine 3',5'-cyclic phosphate + H2O \rightleftharpoons AMP

This enzyme requires Mg2+ or Mn2+ for activity.

References[edit]

  1. ^ Alonso, G.D., Schoijet, A.C., Torres, H.N. and Flawiá, M.M. (2006). "TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi". Mol. Biochem. Parasitol. 145 (1): 40–49. doi:10.1016/j.molbiopara.2005.09.005. PMID 16225937. 
  2. ^ Bader, S., Kortholt, A., Snippe, H. and Van Haastert, P.J. (2006). "DdPDE4, a novel cAMP-specific phosphodiesterase at the surface of Dictyostelium cells". J. Biol. Chem. 281 (29): 20018–20026. doi:10.1074/jbc.M600040200. PMID 16644729. 
  3. ^ Rascón, A., Soderling, S.H., Schaefer, J.B. and Beavo, J.A. (2002). "Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei". Proc. Natl. Acad. Sci. USA 99 (7): 4714–4719. doi:10.1073/pnas.002031599. PMC 123713. PMID 11930017. 
  4. ^ Johner, A., Kunz, S., Linder, M., Shakur, Y. and Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of Leishmania major". BMC Microbiol. 6: #25–25. doi:10.1186/1471-2180-6-25. PMC 1431542. PMID 16522215. 
  5. ^ Lugnier, C., Keravis, T., Le Bec, A., Pauvert, O., Proteau, S. and Rousseau, E. (1999). "Characterization of cyclic nucleotide phosphodiesterase isoforms associated to isolated cardiac nuclei". Biochim. Biophys. Acta 1472 (3): 431–446. doi:10.1016/S0304-4165(99)00145-2. PMID 10564757. 
  6. ^ Imamura, R., Yamanaka, K., Ogura, T., Hiraga, S., Fujita, N., Ishihama, A. and Niki, H. (1996). "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". J. Biol. Chem. 271 (41): 25423–25429. doi:10.1074/jbc.271.41.25423. PMID 8810311. 

External links[edit]