|Jmol-3D images||Image 1
|Molar mass||525.077 g/mol|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
|(what is: / ?)|
3,3'-Diiodothyronine, also known as T2, is a metabolite of thyroid hormone.
It is formed from the breakdown of triiodothyronine. It is an allosteric regulator of the cytochrome c oxidase, the complex IV of the electron transport chain. It increases its activity by preventing the interaction of adenosine triphosphate (ATP) as an allosteric inhibitor.
Levels can be affected in certain disease states.
- Arnold S., Goglia F., Kadenbach B. (1998). "3,5-Diiodothyronine binds to subunit Va of cytochrome-c oxidase and abolishes the allosteric inhibition of respiration by ATP.". Eur J Biochem. 252 (2): 325–330. doi:10.1046/j.1432-1327.1998.2520325.x. PMID 9523704.
- Pinna G, Hiedra L, Meinhold H, et al (September 1998). "3,3'-Diiodothyronine concentrations in the sera of patients with nonthyroidal illnesses and brain tumors and of healthy subjects during acute stress". J. Clin. Endocrinol. Metab. 83 (9): 3071–7. doi:10.1210/jc.83.9.3071. PMID 9745405.