3-(p-Fluorobenzoyloxy)tropane

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3-(p-Fluorobenzoyloxy)tropane
3-(p-Fluorobenzoyloxy)tropane.png
Systematic (IUPAC) name
(1R,5S)-(8-methyl-8-azabicyclo[3.2.1]octan-3-yl)-4-fluorobenzoate
Clinical data
Legal status
?
Routes insufflated
Identifiers
CAS number 172883-97-5 N
ATC code ?
PubChem CID 5147770
ChemSpider 4321292 YesY
Chemical data
Formula C15H18FNO2 
Mol. mass 263.307
 N (what is this?)  (verify)

3β-(p-Fluorobenzoyloxy)tropane, (8-Methyl-8-azabicyclo[3.2.1]oct-3-yl 4-fluorobenzoic acid ester, 4-fluorotropacocaine, 3-Pseudotropyl-4-fluorobenzoate, 3-pseudotropyl-4-fluorobenzoate, pFBT) is a tropane derivative drug which acts as a local anaesthetic, having around 30% the stimulant potency of cocaine but around the same potency as a local anaesthetic.[citation needed] It has been investigated as a potential radiolabelled agent for studying receptor binding,[1] but was not adopted for this application. The main application for fluorotropacocaine however has been as a designer drug analogue of cocaine, first detected by the EMCDDA in 2008,[2][3] and subsequently sold as an ingredient of various "bath salt" powder products, usually mixed in combination with other stimulant drugs such as caffeine, dimethocaine, desoxypipradrol or substituted cathinone derivatives.[4][5]

See also[edit]

References[edit]

  1. ^ Ali M. Emran. New Trends in Radiopharmaceutical Synthesis, Quality Assurance, and Regulatory Control. Springer, 1991. p84. ISBN 0-306-44035-0
  2. ^ Wohlfarth, A.; Weinmann, W. (2010). "Bioanalysis of new designer drugs". Bioanalysis 2 (5): 965–979. doi:10.4155/bio.10.32. PMID 21083227.  edit
  3. ^ Kavanagh P, Angelov D, O'Brien J, Fox J, O'Donnell C, Christie R, Power JD, McDermott SD. The syntheses and characterization 3β-(4-fluorobenzoyloxy)tropane (fluorotropacocaine) and its 3α isomer. Drug Testing and Analysis. 2011 Nov 18. doi:10.1002/dta.362 PMID 22102564
  4. ^ An overview of new psychoactive substances and the outlets supplying them
  5. ^ Reitzel LA, Dalsgaard PW, Müller IB, Cornett C. Identification of ten new designer drugs by GC-MS, UPLC-QTOF-MS, and NMR as part of a police investigation of a Danish Internet company. Drug Testing and Analysis. 2011 Nov 18. doi:10.1002/dta.358 PMID 22102551