3-hydroxyisobutyryl-CoA hydrolase
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| 3-hydroxyisobutyryl-CoA hydrolase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.1.2.4 | ||||||||
| CAS number | 9025-88-1 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / EGO | ||||||||
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In enzymology, a 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) is an enzyme that catalyzes the chemical reaction
- 3-hydroxy-2-methylpropanoyl-CoA + H2O
CoA + 3-hydroxy-2-methylpropanoate
CoA + 3-hydroxy-2-methylpropanoateThus, the two substrates of this enzyme are 3-hydroxy-2-methylpropanoyl-CoA and H2O, whereas its two products are CoA and 3-hydroxy-2-methylpropanoate.
This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, beta-alanine metabolism, and propanoate metabolism.
References [edit]
- Rendina G and Coon MJ (1957). "Enzymatic hydrolysis of the coenzyme A thiol esters of beta-hydroxypropionic and beta-hydroxyisobutyric acids". J. Biol. Chem. 225 (1): 523–534. PMID 13457352.
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