3-hydroxyisobutyryl-CoA hydrolase

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3-hydroxyisobutyryl-CoA hydrolase
Identifiers
EC number 3.1.2.4
CAS number 9025-88-1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 3-hydroxyisobutyryl-CoA hydrolase (EC 3.1.2.4) is an enzyme that catalyzes the chemical reaction

3-hydroxy-2-methylpropanoyl-CoA + H2O \rightleftharpoons CoA + 3-hydroxy-2-methylpropanoate

Thus, the two substrates of this enzyme are 3-hydroxy-2-methylpropanoyl-CoA and H2O, whereas its two products are CoA and 3-hydroxy-2-methylpropanoate.

This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is 3-hydroxy-2-methylpropanoyl-CoA hydrolase. Other names in common use include 3-hydroxy-isobutyryl CoA hydrolase, and HIB CoA deacylase. This enzyme participates in 3 metabolic pathways: valine, leucine and isoleucine degradation, beta-alanine metabolism, and propanoate metabolism.

References[edit]

  • Rendina G and Coon MJ (1957). "Enzymatic hydrolysis of the coenzyme A thiol esters of beta-hydroxypropionic and beta-hydroxyisobutyric acids". J. Biol. Chem. 225 (1): 523–534. PMID 13457352.