3-Isopropylmalate dehydratase

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3-isopropylmalate dehydratase
Identifiers
EC number 4.2.1.33
CAS number 37290-72-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

3-Isopropylmalate dehydratase (E.C.4.2.1.33) is an aconitase homologue,[1][2][3] which catalyses the isomerisation of 2-isopropylmalate to 3-isopropylmalate, via dehydration, in the biosynthesis of leucine.

References[edit]

  1. ^ Gross SR, Burns RO, Umbarger HE (1963). "The biosynthesis of leucine. II. The enzymic isomerization of beta-carboxy-beta-hydroxyisocaproate and alpha-hydroxy-beta-carboxyisocaproate". Biochemistry 2 (5): 1046–52. doi:10.1021/bi00905a023. PMID 14087357. 
  2. ^ Calvo JM, Stevens CM, Kalyanpur MG, Umbarger HE (December 1964). "The absolute configuration of alpha-hydroxy-beta-carboxyisocaproic acid (3-isopropylmalic acid), an intermediate in leucine biosynthesis". Biochemistry 3 (12): 2024–7. doi:10.1021/bi00900a043. PMID 14269331. 
  3. ^ Cole FE, Kalyanpur MG, Stevens CM (August 1973). "Absolute configuration of alpha isopropylmalate and the mechanism of its conversion to beta isopropylmalate in the biosynthesis of leucine". Biochemistry 12 (17): 3346–50. doi:10.1021/bi00741a031. PMID 4270046. 

External links[edit]