3-Mercaptopyruvic acid

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3-Mercaptopyruvic acid
3-Mercaptopyruvic acid.svg
Names
IUPAC name
3-mercapto-2-oxopropanoic acid
Other names
3-MPV; 3-MP
Identifiers
2464-23-5
ChEBI CHEBI:16208 YesY
ChemSpider 96 YesY
Jmol-3D images Image
Image
KEGG C00957 YesY
MeSH 3-mercaptopyruvic+acid
PubChem 98
Properties
C3H4O3S
Molar mass 120.13 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

3-Mercaptopyruvic acid is an intermediate in cysteine metabolism. It has been studied as a potential treatment for cyanide poisoning, but its half-life is too short for it to be clinically effective.[1] Instead, prodrugs, such as sulfanegen, are being evaluated to compensate for the short half-life of 3-mercaptopyruvic acid.[2]

See also[edit]

References[edit]

  1. ^ Nagahara, N; Li, Q; Sawada, N (2003). "Do antidotes for acute cyanide poisoning act on mercaptopyruvate sulfurtransferase to facilitate detoxification?". Current drug targets. Immune, endocrine and metabolic disorders 3 (3): 198–204. doi:10.2174/1568008033340162. PMID 12871026. 
  2. ^ Brenner, M; Kim, JG; Lee, J; Mahon, SB; Lemor, D; Ahdout, R; Boss, GR; Blackledge, W; Jann, L; Nagasawa, HT; Patterson, SE (2010). "Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity". Toxicology and applied pharmacology 248 (3): 269–76. doi:10.1016/j.taap.2010.08.002. PMC 3382974. PMID 20705081.