| County |
Location |
Mile[1] |
Roads intersected |
Notes |
| Hamilton |
Cincinnati |
0.00 |
   US 27 / US 42 / US 52 / US 127
US 22
SR 264 |
SR 3 begins northbound concurrent with US 22 (also its western terminus), US 27, US 42, US 52 and US 127; eastern terminus of SR 264 (eastbound) |
| 0.09 |
   US 27 / US 42 / US 52 / US 127 |
Southbound lanes of US 27, US 42, and US 127 as well as eastbound US 52 enter from the east; westbound SR 264 crosses from east to west. |
| 0.17 |
  US 27 / US 52 / US 127 |
US 22/US 42/SR 3 leaves northbound lanes of concurrency, heading east; northbound US 27/US 127 as well as westbound US 52 continue north. |
| 0.25 |
   US 27 / US 42 / US 52 / US 127
SR 264 |
Southbound lanes of US 27, US 42, and US 127 as well as eastbound US 52 and westbound SR 264 cross from north to south. |
| 0.33 |
US 42 |
Northbound lanes of US 42 leave US 22/SR 3 to the north. |
| 1.45 |
I-71 |
Ramps from eastbound US 22/SR 3 concurrency to northbound I-71 and southbound I-71 to westbound US 22/SR 3 only; I-71 Exit 2. |
| 4.46 |
I-71 |
Northbound exit/southbound entrance to/from interstate only; I-71 Exit 5. |
| Norwood |
6.19 |
SR 561 |
SR 561 joins from the southeast |
| 6.22 |
SR 562 (Norwood Lateral Expressway) |
Full-access interchange with US 22/SR 3/SR 561. |
| 6.29 |
SR 561 |
SR 561 leaves to the northwest. |
| Cincinnati |
11.41 |
I-71 |
Full-access interchange; I-71 Exit 12. |
| Montgomery |
13.30 |
SR 126 (Ronald Reagan Cross County Highway) |
Eastern terminus of expressway; SR 126 joins from the west. |
| 13.57 |
SR 126 |
SR 126 leaves to the east. |
| Sycamore Township |
16.15 |
I-275 |
Full-access interchange; I-275 Exit 50. |
| Warren |
Hamilton Township |
24.69 |
SR 48 |
|
| Morrow |
30.02 |
SR 123 |
SR 123 joins from the north. |
| Salem Township |
31.75 |
SR 123 |
SR 123 leaves to the south. |
| Washington Township |
37.59 |
SR 350 |
|
| Clinton |
Adams Township |
41.73 |
SR 380 |
Southern terminus of SR 380. |
| Wilmington |
47.20 |
SR 73 |
SR 73 joins from the northwest. |
| 48.06 |
 US 68 / SR 134 |
|
| 50.63 |
SR 73 |
SR 73 leaves to the south. |
| Richland Township |
56.81 |
SR 72 |
|
| Sabina |
58.95 |
SR 729 |
|
| Fayette |
Union Township |
68.58 |
US 35 |
Full-access interchange with US 35 expressway, shared with US 62 to the south. |
| Washington Court House |
69.75 |
US 62
SR 41 |
US 62 joins from the southwest; SR 41 joins from the south. |
| 70.23 |
SR 41
US 35 |
SR 41 leaves to the northwest; former southeastbound alignment of US 35. |
| 70.38 |
US 22
SR 38 |
US 22 leaves to the east; SR 38 begins, joining US 62/SR 3. |
| Union Township |
74.85 |
SR 238 |
Southern terminus of SR 238. |
| Madison |
Mount Sterling |
85.63 |
SR 207 |
SR 207 joins from the south. |
| 85.89 |
 SR 56 / SR 207 |
SR 207 leaves northwest concurrent with SR 56; SR 56 continues southeast. |
| Pickaway |
Darby Township |
93.6[3] |
CR 501 |
Former routing of SR 3 |
| 94.08 |
SR 762 |
Northern terminus of SR 762 |
| Franklin |
Pleasant Township |
94.5[3] |
Columbus Street |
Former routing of SR 3 |
| 95.0[3] |
Old Harrisburg Road |
Former routing of SR 3 |
| 95.7[3] |
Old Harrisburg Road |
Former routing of SR 3 |
| 96.18 |
I-71 |
Full-access interchange; I-71 Exit 94. |
| 97.72 |
SR 665 |
|
| Jackson Township |
102.66 |
I-270 |
Full-access interchange; I-270 Exit 2. |
| Columbus |
106.46 |
I-70 |
Full-access via side streets to the south and north of crossing; I-70 Exit 98A-B. |
| 107.98 |
SR 315 |
Full-access interchange from SR 315. |
| 109.15 |
 US 23 south / US 33 south |
|
| 109.25 |
 US 23 north / US 33 north |
Southern terminus of US 23/US 33/US 62/SR 3 concurrency |
| 109.68 |
  US 40 / US 62 / SR 16 |
US 62 leaves to the east, concurrent with US 40 and SR 16 which continue west |
| 109.88 |
 US 23 / US 33 |
US 23 leaves to the north; US 33 leaves to the west 0.1 mi. later |
| 110.62 |
I-670 |
I-670 Exits 4C (eastbound) and 5 (westbound); westbound exit/entrance via Jack Gibbs Blvd. |
| 111.90 |
I-71 |
SR 3 passes under I-71 here; full access to I-71 (Exit 110A) via East 5th Avenue 0.4 mi. before, and to I-71 (Exit 110B) via East 11th Avenue 0.3 mi. later. |
| Minerva Park |
118.93 |
SR 161 (Dublin-Granville Road) |
Full-access interchange with expressway. |
| Blendon Township |
120.39 |
I-270 |
Full-access interchange; I-270 Exit 29. |
| Delaware |
Genoa Township |
124.3[3] |
South Old 3C Highway |
Former routing of SR 3 |
| Sunbury |
131.47 |
 US 36 / SR 37
SR 61 |
US 36 joins from the northwest concurrent with SR 37; SR 37 continues to the southeast; SR 61 begins concurrent with US 36/SR 3 concurrency. |
| 131.90 |
SR 61 |
SR 61 leaves to the north |
| Trenton Township |
132.5[3] |
North Old 3C Road |
Former routing of SR 3 |
| 135.8[3] |
CR 605 |
Former northern terminus of SR 605 |
| 136.5[3] |
North Old 3C Road |
Former routing of SR 3 |
| 137.3[3] |
Locust Road |
Former routing of SR 3 |
| Knox |
Centerburg |
142.13 |
SR 314 |
Southern terminus of SR 314. |
| Hilliar Township |
143.22 |
SR 657 |
Western terminus of SR 657. |
| Clinton Township |
153.4[3] |
Columbus Road |
Former routing of SR 3 |
| 154.89 |
SR 229 |
SR 229 joins from the west. |
| Mount Vernon |
155.85 |
SR 13 |
SR 13 southbound directional alternate joins from the north. |
| 155.97 |
 SR 13 / SR 229 |
SR 13 southbound directional alternate and SR 229 eastbound leave to the south (concurrency). |
| 156.11 |
 US 36 / SR 229 |
US 36 leaves to the east; US 36/SR 229 westbound directional alternate enters from the east. |
| 156.16 |
 US 36 / SR 229 |
US 36/SR 229 westbound directional alternate leaves to the west. |
| 156.18 |
SR 13 |
Northbound SR 13 crosses from east to west. |
| Monroe Township |
158.92 |
SR 768 |
Northern terminus of SR 768. |
| Brown Township |
170.64 |
SR 205 |
Northern terminus of SR 205. |
| Ashland |
Hanover Township |
176.38 |
SR 97 |
Eastern terminus of SR 97. |
| Loudonville |
178.98 |
SR 39 |
SR 39 joins from the west. |
| 179.13 |
 SR 39 / SR 60 |
SR 39 leaves to the east concurrent with SR 60; SR 3/SR 60 concurrency continues north. |
| 179.30 |
SR 60 |
SR 60 leaves to the north. |
| Holmes |
Washington Township |
184.19 |
 SR 179 / SR 226 |
SR 226 begins east, concurrent with SR 179, which continues north. |
| Wayne |
Wooster Township |
195.86 |
SR 226 |
Northern terminus of SR 226; former northbound alignment of SR 3. |
| 196.43 |
SR 95 |
Eastern terminus of SR 95 |
| 197.2[3] |
Columbus Avenue |
Former routing of SR 3 |
| Wooster |
197.95 |
 US 30 / US 250 (Lincoln Way) |
SR 3 joins expressway via full-access interchange; former northbound alignment of SR 3. |
| 198.62 |
SR 302 |
Full-access interchange. |
| Wooster Township |
199.57 |
US 250 |
Full-access interchange (direct ramp eastbound; westbound via Pittsburgh Avenue) |
| 200.15 |
US 30 |
US 30 leaves to the east at full-access interchange. |
| 200.33 |
SR 83 |
SR 83 joins from the south at full-access interchange. |
| Wooster |
201.08 |
SR 585 |
Southern terminus of SR 585 (former cross-alignment) at full-access interchange. |
| 203.26 |
SR 83 |
SR 3 leaves expressway; SR 83 continues northwest; former cross-alignment of SR 3. |
| Canaan Township |
210.85 |
SR 604 |
|
| Medina |
Seville |
217.95 |
 I-76 / US 224 |
Full-access interchange; I-76 Exit 2. |
| Montville Township |
222.56 |
SR 162 |
SR 162 joins from the west. |
| 223.05 |
SR 162 |
SR 162 leaves to the east. |
| Medina |
224.96 |
US 42
SR 57 |
US 42 joins from the west; SR 57 joins from the east. |
| 225.22 |
SR 18 |
SR 18 eastbound lanes cross. |
| 225.30 |
US 42
 SR 18 / SR 57 |
US 42 leaves to the north; SR 18 westbound lanes, concurrent with SR 57, leave to the west. |
| 225.36 |
 SR 18 / SR 57 |
SR 18 westbound lanes, concurrent with SR 57, join from the south. |
| Medina Township |
231.04 |
I-71 |
Full-access interchange; I-71 Exit 222. |
| Hinckley Township |
232.03 |
SR 606 |
Western terminus of SR 606. |
| 233.63 |
SR 94 |
SR 94 joins from the south. |
| 234.66 |
SR 606 |
|
| 236.16 |
 SR 94 / SR 303 |
SR 94 leaves to the east concurrent with SR 303 which continues west. |
| Cuyahoga |
North Royalton |
241.55 |
SR 82 |
|
| Parma |
248.50 |
US 42 |
SR 3 joins US 42, end sign is posted. |
| Cleveland |
254.60 |

  Alt US 6/US 6/US 20 |
US 42 and SR 3 join US 6 and US 20. |
| 255.48 |
US 20/Public Square west |
US 20 leaves. |
| 255.53 |
    US 422/SR 8/SR 14/SR 43/SR 87/Public Square |
|
| 255.58 |
US 322/Public Square east |
|