3F8

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3F8 ?
Monoclonal antibody
Source Mouse
Target GD2
Clinical data
Legal status
?
Routes intravenous
Identifiers
CAS number 339169-93-6 N
ATC code None
Chemical data
Formula ?
 N (what is this?)  (verify)

3F8 is a murine IgG3[1] monoclonal antibody which binds to GD2.[2]

It has been used in the detection and treatment of neuroblastoma.[3] For imaging neuroblastoma, it is labelled with one of the radioisotopes iodine-124 and iodine-131.[4][5]

See also[edit]

References[edit]

  1. ^ Kushner BH, Cheung NK (1989). "GM-CSF enhances 3F8 monoclonal antibody-dependent cellular cytotoxicity against human melanoma and neuroblastoma". Blood 73 (7): 1936–41. PMID 2653466. 
  2. ^ "Sloan-Kettering - Neuroblastoma: 3F8 Monoclonal Antibody Therapy Q & A". Retrieved 2008-02-19. 
  3. ^ Weinstein, J. L. (1 June 2003). "Advances in the Diagnosis and Treatment of Neuroblastoma". The Oncologist 8 (3): 278–292. doi:10.1634/theoncologist.8-3-278. 
  4. ^ Yeh SD, Larson SM, Burch L et al. (1991). "Radioimmunodetection of neuroblastoma with iodine-131-3F8: correlation with biopsy, iodine-131-metaiodobenzylguanidine and standard diagnostic modalities". J. Nucl. Med. 32 (5): 769–76. PMID 1902508. 
  5. ^ Dauer LT, St Germain J, Williamson MJ et al. (2007). "Whole-body clearance kinetics and external dosimetry of 131I-3F8 monoclonal antibody for radioimmunotherapy of neuroblastoma". Health Phys 92 (1): 33–9. doi:10.1097/01.HP.0000231583.32904.6c. PMID 17164597.