4'-Fluorococaine

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4'-Fluorococaine
4-fluorococaine.png
Systematic (IUPAC) name
methyl (1R,2R,3S,5S)-3-(4-fluorobenzoyloxy)-8-methyl-8-azabicyclo[3.2.1] octane-2-carboxylate
Clinical data
Legal status ?
Identifiers
CAS number 134507-62-3
ATC code ?
PubChem CID 126112
ChemSpider 112124 YesY
Chemical data
Formula C17H20FNO4 
Mol. mass 321.343
 YesY (what is this?)  (verify)

4'-Fluorococaine is a tropane derivative drug which is a synthetic analogue of cocaine. Unlike related compounds such as the corresponding 4'-fluorophenyltropane derivative CFT and the 2'-hydroxy analogue salicylmethylecgonine, 4'-fluorococaine has only around the same potency as cocaine as an inhibitor of dopamine reuptake, but conversely it is a much stronger serotonin reuptake inhibitor than cocaine, resulting in a significantly altered pharmacological profile in animal studies.[1]

See also[edit]

References[edit]

  1. ^ Gatley, S. J.; Yu, D. W.; Fowler, J. S.; MacGregor, R. R.; Schlyer, D. J.; Dewey, S. L.; Wolf, A. P.; Martin, T.; Shea, C. E.; Volkow, N. D. (2008). "Studies with Differentially Labeled [11C]Cocaine, [11C]Norcocaine, [11C]Benzoylecgonine, and [11C]-and 4′-[18F]Fluorococaine to Probe the Extent to Which [11C]Cocaine Metabolites Contribute to PET Images of the Baboon Brain". Journal of Neurochemistry 62 (3): 1154–1162. doi:10.1046/j.1471-4159.1994.62031154.x. PMID 8113802.  edit