4,5-dihydroxyphthalate decarboxylase

4,5-dihydroxyphthalate decarboxylase
Identifiers
EC number	4.1.1.55
CAS number	37290-48-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a 4,5-dihydroxyphthalate decarboxylase (EC 4.1.1.55) is an enzyme that catalyzes the chemical reaction

4,5-dihydroxyphthalate $\rightleftharpoons$ 3,4-dihydroxybenzoate + CO₂

Hence, this enzyme has one substrate, 4,5-dihydroxyphthalate, and two products, 3,4-dihydroxybenzoate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming). This enzyme is also called 4,5-dihydroxyphthalate carboxy-lyase. This enzyme participates in 2,4-dichlorobenzoate degradation.

References

• Ribbons DW and Evans WC (1966). "Oxidative metabolism of phthalic acid by soil pseudomonads". Biochem. J. 76: 310–318.