4-(hydroxymethyl)benzenesulfonate dehydrogenase

4-(hydroxymethyl)benzene-sulfonate dehydrogenase
Identifiers
EC number	1.1.1.257
CAS number	167973-64-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a 4-(hydroxymethyl)benzenesulfonate dehydrogenase (EC 1.1.1.257) is an enzyme that catalyzes the chemical reaction

4-(hydroxymethyl)benzenesulfonate + NAD⁺ $\rightleftharpoons$ 4-formylbenzenesulfonate + NADH + H⁺

Thus, the two substrates of this enzyme are 4-(hydroxymethyl)benzenesulfonate and NAD⁺, whereas its 3 products are 4-formylbenzenesulfonate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase. This enzyme participates in 2,4-dichlorobenzoate degradation.

References

• Cook AM; Saller, E; Schläfli Oppenberg, HR; Kroneck, PM; Leisinger, T; Cook, AM (Pt 9). "Degradative pathways for p-toluenecarboxylate and p-toluenesulfonate and their multicomponent oxygenases in Comamonas testosteroni strains PSB-4 and T-2". Microbiology. 142 (9): 2419–27. doi:10.1099/00221287-142-9-2419. PMID 8828208.