4-Chloromercuribenzoic acid

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4-Chloromercuribenzoic acid[1]
4-chloromercuribenzoic acid.png
Abbreviations PCMB
CAS number 59-85-8 YesY
PubChem 1730
ChemSpider 1667 YesY
ChEBI CHEBI:28420 YesY
Jmol-3D images Image 1
Molecular formula C7H5ClHgO2
Molar mass 357.16 g mol−1
Melting point 287 °C (549 °F; 560 K) (dec.)
R-phrases R26/27/28 R33 R50/53
S-phrases S13 S28 S36 S45 S60 S61
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

4-Chloromercuribenzoic acid (p-chloromercuribenzoic acid, PCMB) is an organomercury compound that is used as a protease inhibitor, especially in molecular biology applications.

PCMB reacts with thiol groups in proteins and is therefore an inhibitor of enzymes that are dependent on thiol reactivity, including cysteine proteases such as papain and acetylcholinesterase. Because of this reactivity with thiols, PCMB is also used in titrimetric quantification of thiol groups in proteins.