4-Chloromercuribenzoic acid

From Wikipedia, the free encyclopedia
Jump to: navigation, search
4-Chloromercuribenzoic acid[1]
4-chloromercuribenzoic acid.png
IUPAC name
Other names
p-Chloromercurybenzoic acid; p-Chloromercuribenzoate; 4-Chloromercuribenzoate
Abbreviations PCMB
59-85-8 YesY
ChEBI CHEBI:28420 YesY
ChEMBL ChEMBL575867 YesY
ChemSpider 1667 YesY
Jmol-3D images Image
PubChem 1730
Molar mass 357.16 g·mol−1
Melting point 287 °C (549 °F; 560 K) (dec.)
R-phrases R26/27/28 R33 R50/53
S-phrases S13 S28 S36 S45 S60 S61
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY verify (what isYesY/N?)
Infobox references

4-Chloromercuribenzoic acid (p-chloromercuribenzoic acid, PCMB) is an organomercury compound that is used as a protease inhibitor, especially in molecular biology applications.

PCMB reacts with thiol groups in proteins and is therefore an inhibitor of enzymes that are dependent on thiol reactivity, including cysteine proteases such as papain and acetylcholinesterase. Because of this reactivity with thiols, PCMB is also used in titrimetric quantification of thiol groups in proteins.