The effects of 4-HO-DiPT are broadly comparable to those of other serotonergic psychedelics such as LSD and psilocybin, but they are distinguished by their relative brevity. 4-HO-DiPT is orally active at 15-20 mg, and its effects last for 2-3 hours. Shulgin "doubt[s] that there is another psychedelic drug, anywhere, that can match this one for speed, for intensity, for brevity, and sensitive to dose, at least one that is active orally." An idiosyncratic effect of the drug, also noted by Shulgin, is its tendency to induce tremors.
Some users have reported a minor audio distortion with lower dosages. Higher dosages increase the polarity of the distortion. It is defined as being slightly lower in pitch and creating several different effects, such as pitch bend, volume distortion, and rate distortion. As with most DiPT psychedelics, music can become more dissonant and less harmonious. Users have also reported a visual distortion widely comparable to the hallucinogen LSD.
Higher doses of 4-HO-DIPT, such as those above 30 mgs can increase the duration of the effects significantly.