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IUPAC name
Other names
4-hydroxy-N-methyl-N-ethyltryptamine; metocin; 3-{2-[ethyl(methyl)amino]ethyl}-1H-indol-4-ol
77872-41-4 N
ChemSpider 10513072 YesY
Jmol-3D images Image
PubChem 21786582
Molar mass 218.29 g·mol−1
Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

4-HO-MET (4-hydroxy-N-methyl-N-ethyltryptamine, or metocin, methylcybin, Colour), is a lesser-known psychedelic drug. It is a structural− and functional analog of psilocin as well the 4-hydroxyl analog of MET. 4-HO-MET was first synthesized by Alexander Shulgin. In his book TiHKAL (Tryptamines I Have Known and Loved), the dosage is listed as 10-20 mg.[1] 4-HO-MET produces psilocin-like distortion of color, sound, and form. Very little data exists about the pharmacological properties, metabolism, and toxicity of 4-HO-MET. There have been no reports of deaths from 4-HO-MET, even though people have reported taking doses up to 150 mg,[2] more than an order of magnitude above the effective dose.[3]


Users report similar effects to psilocin, including mydriasis, closed and open eye visuals, euphoria, time dilation and general change in thought processes. These effects occur in a wavelike pattern such as that of psilocybin with near-normal perception and high effect varying rapidly. The effects last for about 4–6 hours.[4]


Similar to O-acetylpsilocin, a dose ranges from around 8 mg to 30 mg. However, this varies greatly as some report very heavy experiences with doses as low as 17 mg, yet others report light experiences with doses as high as 30 mg.[5]

Metocin Oral Dose
Threshold 2 mg-8 mg
Light 5 mg-10 mg
Common 8 mg-15 mg
Strong 15 mg-30 mg
Heavy 45 mg+

Drug prohibition laws[edit]


Sveriges riksdag added 4-HO-MET to schedule I ("substances, plant materials and fungi which normally do not have medical use") as narcotics in Sweden as of May 1, 2012, published by Medical Products Agency in their regulation LVFS 2012:6 listed as 4-HO-MET 3-[2-[etyl(metyl)amino]etyl]-1H-indol-4-ol.[6]

United Kingdom[edit]

4-HO-MET is a class A drug in the UK, as a result of the tryptamine catch-all clause.

See also[edit]


External links[edit]