4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

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4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
Identifiers
EC number 1.17.7.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (EC 1.17.7.1) is an enzyme that catalyzes the chemical reaction

(E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + H2O + protein-disulfide \rightleftharpoons 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + protein-dithiol

The 3 substrates of this enzyme are (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HMB-PP), water, and protein disulfide, whereas its two products are 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and protein dithiol.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH2 groups with a disulfide as acceptor. The systematic name of this enzyme class is (E)-4-hydroxy-3-methylbut-2-en-1-yl-diphosphate:protein-disulfide oxidoreductase (hydrating). This enzyme participates in biosynthesis of steroids.

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