4-hydroxy-tetrahydrodipicolinate synthase

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4-hydroxy-tetrahydrodipicolinate synthase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

4-hydroxy-tetrahydrodipicolinate synthase (EC, dihydrodipicolinate synthase, dihydropicolinate synthetase, dihydrodipicolinic acid synthase, L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing), dapA (gene).) is an enzyme with system name L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing; (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinate-forming).[1][2][3][4] This enzyme catalyses the following chemical reaction

pyruvate + L-aspartate-4-semialdehyde \rightleftharpoons (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O

The reaction proceeds in three consecutive steps.


  1. ^ Yugari, Y. and Gilvarg, C. (1965). "The condensation step in diaminopimelate synthesis". J. Biol. Chem. 240: 4710–4716. PMID 5321309. 
  2. ^ Blickling, S., Renner, C., Laber, B., Pohlenz, H.D., Holak, T.A. and Huber, R. (1997). "Reaction mechanism of Escherichia coli dihydrodipicolinate synthase investigated by X-ray crystallography and NMR spectroscopy". Biochemistry 36: 24–33. doi:10.1021/bi962272d. PMID 8993314. 
  3. ^ Devenish, S.R., Blunt, J.W. and Gerrard, J.A. (2010). "NMR studies uncover alternate substrates for dihydrodipicolinate synthase and suggest that dihydrodipicolinate reductase is also a dehydratase". J Med Chem 53: 4808–4812. doi:10.1021/jm100349s. PMID 20503968. 
  4. ^ Soares da Costa, T.P., Muscroft-Taylor, A.C., Dobson, R.C., Devenish, S.R., Jameson, G.B. and Gerrard, J.A. (2010). "How essential is the ’essential’ active-site lysine in dihydrodipicolinate synthase". Biochimie 92: 837–845. doi:10.1016/j.biochi.2010.03.004. PMID 20353808. 

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