4-hydroxybenzoyl-CoA reductase

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4-hydroxybenzoyl-CoA reductase
EC number
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a 4-hydroxybenzoyl-CoA reductase (EC is an enzyme found in some bacteria and archaea that catalyzes the chemical reaction

benzoyl-CoA + acceptor + H2O \rightleftharpoons 4-hydroxybenzoyl-CoA + reduced acceptor

The 3 substrates of this enzyme are benzoyl-CoA, acceptor, and H2O, whereas its two products are 4-hydroxybenzoyl-CoA and reduced acceptor.

This enzyme participates in benzoate degradation via coa ligation.


This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is benzoyl-CoA:acceptor oxidoreductase. Other names in common use include:

  • 4-hydroxybenzoyl-CoA reductase (dehydroxylating), and
  • 4-hydroxybenzoyl-CoA:(acceptor) oxidoreductase.


Further reading[edit]

  • Glockler R, Tschech A, Fuchs G (1989). "Reductive dehydroxylation of 4-hydroxybenzoyl-CoA to benzoyl-CoA in a denitrifying, phenol-degrading Pseudomonas species". FEBS. Lett. 251 (1-2): 237–40. doi:10.1016/0014-5793(89)81461-9. PMID 2753161. 
  • Heider J, Boll M, Breese K, Breinig S, Ebenau-Jehle C, Feil U, Gad'on N, Laempe D, Leuthner B, Mohamed ME, Schneider S, Burchhardt G, Fuchs G (August 1998). "Differential induction of enzymes involved in anaerobic metabolism of aromatic compounds in the denitrifying bacterium Thauera aromatica". Arch. Microbiol. 170 (2): 120–31. doi:10.1007/s002030050623. PMID 9683649. 
  • Breese K, Fuchs G (1998). "4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from the denitrifying bacterium Thauera aromatica--prosthetic groups, electron donor, and genes of a member of the molybdenum-flavin-iron-sulfur proteins". Eur. J. Biochem. 251 (3): 916–23. doi:10.1046/j.1432-1327.1998.2510916.x. PMID 9490068. 
  • Brackmann R, Fuchs G (1993). "Enzymes of anaerobic metabolism of phenolic compounds 4-Hydroxybenzoyl-CoA reductase (dehydroxylating) from a denitrifying Pseudomonas species". Eur. J. Biochem. 213 (1): 563–71. doi:10.1111/j.1432-1033.1993.tb17795.x. PMID 8477729. 
  • Heider J, Fuchs G (1997). "Anaerobic metabolism of aromatic compounds". Eur. J. Biochem. 243 (3): 577–96. doi:10.1111/j.1432-1033.1997.00577.x. PMID 9057820.