5-HT1D receptor

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5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled
Identifiers
Symbols HTR1D ; 5-HT1D; HT1DA; HTR1DA; HTRL; RDC4
External IDs OMIM182133 MGI96276 HomoloGene20240 IUPHAR: 5-HT1D ChEMBL: 1983 GeneCards: HTR1D Gene
RNA expression pattern
PBB GE HTR1D 207368 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 3352 15552
Ensembl ENSG00000179546 ENSMUSG00000070687
UniProt P28221 Q61224
RefSeq (mRNA) NM_000864 NM_008309
RefSeq (protein) NP_000855 NP_032335
Location (UCSC) Chr 1:
23.52 – 23.52 Mb
Chr 4:
136.42 – 136.44 Mb
PubMed search [1] [2]

5-hydroxytryptamine (serotonin) receptor 1D, also known as HTR1D, is a 5-HT receptor, but also denotes the human gene encoding it.[1] 5-HT1D acts on the central nervous system, and affects locomotion and anxiety. It also induces vascular vasoconstriction in the brain.

Ligands[edit]

Agonists[edit]

  • 5-(Nonyloxy)tryptamine,[2]
  • sumatriptan (vasoconstrictor in migraine)
  • 5-Carboxamidotryptamine (5-CT)
  • 5-(t-Butyl)-N-methyltryptamine[3]
  • CP-135,807
  • CP-286,601
  • PNU-109,291 ((S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide)
  • PNU-142,633 ((1S)-1-[2-[4-[4-(Aminocarbonyl)phenyl]-1-piperazinyl]ethyl]-3,4-dihydro-N-methyl-1H-2-benzopyran-6-carboxamide)
  • GR-46611 (3-[3-(2-Dimethylaminoethyl)-1H-indol-5-yl]-N-(4-methoxybenzyl)acrylamide)
  • L-694,247 (2-[5-[3-(4-Methylsulfonylamino)benzyl-1,2,4-oxadiazol-5-yl]-1H-indol-3-yl]ethanamine)
  • L-772,405

Antagonists[edit]

See also[edit]

References[edit]

  1. ^ "Entrez Gene: HTR1D 5-hydroxytryptamine (serotonin) receptor 1D". 
  2. ^ Glennon RA, Hong SS, Dukat M, Teitler M, Davis K (1994). "5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1Dβ serotonin receptor agonist". Journal of Medicinal Chemistry 37 (18): 2828–2830. doi:10.1021/jm00044a001. PMID 8071931. 
  3. ^ Xu YC, Schaus JM, Walker C, Krushinski J, Adham N, Zgombick JM, Liang SX, Kohlman DT, Audia JE (1999). "N-Methyl-5-tert-butyltryptamine: A novel, highly potent 5-HT1D receptor agonist". Journal of Medicinal Chemistry 42 (3): 526–531. doi:10.1021/jm9805945. PMID 9986723. 

External links[edit]

  • "5-HT1D". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.