5.8S ribosomal RNA
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| 5.8S ribosomal RNA | |
|---|---|
 |
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| Predicted secondary structure and sequence conservation of 5.8S ribosomal RNA | |
| Identifiers | |
| Symbol | 5_8S_rRNA |
| Rfam | RF00002 |
| Other data | |
| RNA type | Gene; rRNA |
| Domain(s) | Eukaryota; Archaea |
| GO | 0003735 0005840 |
| SO | 0000375 |
In molecular biology the 5.8S ribosomal RNA (5.8S rRNA) is a non-coding RNA component of the large subunit of the eukaryotic ribosome and so plays an important role in protein translation. It is transcribed by RNA polymerase I as part of the 45S precursor that also contains 18S and 28S rRNA. Its function is thought to be in 5.8S rRNA ribosome translocation.[1] It is also known to form covalent linkage to the p53 tumour suppressor protein.[2] 5.8S rRNA is also found in archaea.
5.8S rRNA can be used as a reference gene for miRNA detection.[3]
[edit] References
- ^ Abou, Elela S; Nazar RN (1997). "Role of the 5.8S rRNA in ribosome translocation". Nucleic Acids Res 25 (9): 1788–1794. doi:10.1093/nar/25.9.1788. PMC 146658. PMID 9108162. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=146658.
- ^ Fontoura, BM; Atienza CA, Sorokina EA, Morimoto T, Carroll RB (1997). "Cytoplasmic p53 polypeptide is associated with ribosomes". Mol Cell Biol 17 (6): 3146–3154. PMC 232167. PMID 9154813. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232167.
- ^ Shi R, Chiang VL (October 2005). "Facile means for quantifying microRNA expression by real-time PCR". BioTechniques 39 (4): 519–25. doi:10.2144/000112010. PMID 16235564. http://www.biotechniques.com/article/000112010. Retrieved 2010-09-15.
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