|Centuries:||5th century – 6th century – 7th century|
|Decades:||510s 520s 530s – 540s – 550s 560s 570s|
|Years:||543 544 545 – 546 – 547 548 549|
|546 by topic|
|State leaders – Sovereign states|
|Birth and death categories|
|Births – Deaths|
|Establishment and disestablishment categories|
|Establishments – Disestablishments|
|Ab urbe condita||1299|
|Bahá'í calendar||−1298 – −1297|
|English Regnal year||N/A|
|Chinese calendar||乙丑年 (Wood Ox)
3242 or 3182
— to —
丙寅年 (Fire Tiger)
3243 or 3183
|- Vikram Samvat||602–603|
|- Shaka Samvat||468–469|
|- Kali Yuga||3647–3648|
|Igbo calendar||−454 – −453|
|Iranian calendar||76 BP – 75 BP|
|Islamic calendar||78 BH – 77 BH|
|Minguo calendar||1366 before ROC
|Thai solar calendar||1089|
|Wikimedia Commons has media related to 546.|
Year 546 (DXLVI) was a common year starting on Monday (link will display the full calendar) of the Julian calendar. The denomination 546 for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.
- Siege of Rome: The Ostrogoths under king Totila retake Rome, by bribing the Byzantine garrison. Belisarius tries to relieve the city, but Gothic ships intercept the imperial fleet near the mouth of the Tiber.
- December 17 – Totila plunders Rome and destroys the fortifications of the city.He withdraws the Gothic army and moves into Apulia (Southern Italy).
- Winter – Pope Vigilius arrives in Constantinople to meet with emperor Justinian I. The future pope Pelagius is sent by Totila to negotiate with Justinian.
- Audoin succeeds Walthari as king of the Lombards. He is murdered, in order to gain the throne for himself.
- Audoin receives subsidies, Justinian I encourages him to battle the Gepids in the Carpathian Mountains.
- Audoin leads the Lombards across the Danube into Pannonia and becomes an ally of the Byzantines.
- The Basilica of San Vitale (Ravenna) is completed by bishop Maximianus during the Byzantine Exarchate of Ravenna.
- The Diocese of Bangor is established in the Welsh kingdom of Gwynedd with Deiniol consecrated as first bishop (approximate date).