6-APA
| 6-Aminopenicillanic acid | |
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(2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4- thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid |
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| Identifiers | |
| CAS number | 551-16-6  |
| PubChem | 11082 |
| ChemSpider | 10611 |
| ChEBI | CHEBI:57869 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C8H12N2O3S |
| Molar mass | 216.25 g/mol |
| Melting point |
198 - 200 °C |
| Boiling point |
> 200 °C (decomposes) |
 (verify) (what is:  / ?)Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
6-APA is the chemical compound (+)-6-aminopenicillanic acid. [1]
Contents |
[edit] Use
6-APA is the core of penicillins. It is obtained from the fermentation brew of the Penicillium mold and used as the main starting block for the preparation of numerous semisynthetic penicillins.
[edit] Manufacture
This useful compound is made as follows:
Weissenburger, H. W. O.; Van der Hoven, M. G.; Recl. Trav. Chim. Pays-Bas 1970, 89, 1081.
[edit] References
- ^ F.P. Doyle, J.H.C. Nayler, G.N. Rolinson US Patent 2,941,995, filed July 22, 1958, granted June 21, 1960. Recovery of solid 6-aminopenicillanic acid.
