6-Methyl-MDA

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6-Methyl-MDA
6-Methyl-MDA.png
Systematic (IUPAC) name
1-(6-methyl-1,3-benzodioxol-5-yl)propan-2-amine
Clinical data
Legal status
Routes Oral
Identifiers
ATC code None
PubChem CID 10511982
ChemSpider 8687383 YesY
ChEMBL CHEMBL6376 YesY
Chemical data
Formula C11NO2 
Mol. mass 193.24 g/mol
 YesY (what is this?)  (verify)

6-Methyl-3,4-methylenedioxyamphetamine (6-Methyl-MDA) is an entactogen and psychedelic drug of the amphetamine class.[1] It was first synthesized in the late 1990s by a team including David E. Nichols at Purdue University while investigating derivatives of MDA and MDMA.[1]

6-Methyl-MDA has IC50 values of 783nM, 28,300nM, and 4,602nM for inhibiting the reuptake of serotonin, dopamine, and norepinephrine in rat synaptosomes.[1] In animal studies it substitutes for MBDB, MMAI, LSD, and DOI, though not amphetamine, but only partially and at high doses.[1] Thus, while several-fold less potent than its analogues 2-methyl-MDA and 5-methyl-MDA, and approximately half as potent as MDA, 6-methyl-MDA is still significantly active,[1] and appropriate doses may be similar to or somewhat higher than those of MDMA.[citation needed]

See also[edit]

References[edit]

  1. ^ a b c d e Parker MA, Marona-Lewicka D, Kurrasch D, Shulgin AT, Nichols DE (March 1998). "Synthesis and pharmacological evaluation of ring-methylated derivatives of 3,4-(methylenedioxy)amphetamine (MDA)". Journal of Medicinal Chemistry 41 (6): 1001–5. doi:10.1021/jm9705925. PMID 9526575.