7,12-Dimethylbenz(a)anthracene

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7,12-Dimethylbenz(a)anthracene[1]
DMBA.png
7,12-Dimethylbenz(a)anthracene ballstick.png
Identifiers
CAS number 57-97-6 YesY
PubChem 6001
ChemSpider 5779 YesY
ChEBI CHEBI:254496 YesY
ChEMBL CHEMBL329673 YesY
Jmol-3D images Image 1
Properties
Molecular formula C20H16
Molar mass 256.34104
Melting point 122–123 °C
Hazards
R-phrases R45 R22
S-phrases S53 S36/37 S45
Main hazards T (Toxic)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 YesY (verify) (what is: YesY/N?)
Infobox references

7,12-Dimethylbenz(a)anthracene is an immunosuppressor and a powerful organ-specific laboratory carcinogen.[2] Also known as 7,12-dimethylbenz[α]anthracene or DMBA, this substance is widely used in many research laboratories studying cancer. DMBA serves as a tumor initiator. Tumor promotion can be induced with treatments of TPA (12-O-tetradecanoylphorbol-13-acetate) in some models of two-stage carcinogenesis.[3] This allows for a greatly accelerated rate of tumor growth, making many cancer studies possible.

References[edit]

  1. ^ 7,12-Dimethylbenz(a)anthracene at Sigma-Aldrich
  2. ^ Miyata M, Furukawa M, Takahashi K, Gonzalez FJ, Yamazoe Y. (2001) Mechanism of 7, 12-Dimethylbenz[a]anthracene-Induced Immunotoxicity: Role of Metabolic Activation at the Target Organ. Jpn J Pharmacol 86:302-309. Link
  3. ^ Sung YM, He G, Fischer, SM. (2005) Lack of Expression of the EP2 but not EP3 Receptor for Prostaglandin E2 Results in Suppression of Skin Tumor Development. Cancer Res 65:9304-9311