7-Chlorokynurenic acid

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7-Chlorokynurenic acid
7-Chlorokynurenate.png
Identifiers
ChemSpider 1813
Jmol-3D images Image 1
Properties
Molecular formula C10H6ClNO3
Molar mass 223.61 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

7-Chlorokynurenic acid (7-CTKA) is a NMDA receptor antagonist with antidepressant activity in rats.[1][2]

References[edit]

  1. ^ Kemp, JA; Foster, AC; Leeson, PD; Priestley, T; Tridgett, R; Iversen, LL; Woodruff, GN (1988). "7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex". Proceedings of the National Academy of Sciences of the United States of America 85 (17): 6547–6550. doi:10.1073/pnas.85.17.6547. PMC 282010. 
  2. ^ Zhu, WL; Wang, SJ; Liu, MM; Shi, HS; Zhang, RX; Liu, JF; Ding, ZB; Lu, L (2013). "Glycine site N-methyl-D-aspartate receptor antagonist 7-CTKA produces rapid antidepressant-like effects in male rats". Journal of psychiatry & neuroscience : JPN 38 (5): 306–16. doi:10.1503/jpn.120228. PMC 3756114. PMID 23611177.