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CAS number 560085-11-2 YesY
PubChem 10236758
ChemSpider 8412246 YesY
Jmol-3D images Image 1
Molecular formula C21H32N2O
Molar mass 328.49 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
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Infobox references

77-LH-28-1 is a selective agonist of muscarinic acetylcholine receptor subtype 1 (M1) discovered in 2008. It is an allosteric agonist, exhibiting over 100-fold specificity for M1 over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood brain barrier and is therefore a useful pharmocologic tool with cognition enhancing effects.[1]


  1. ^ C J Langmead, N E Austin, C L Branch, J T Brown, K A Buchanan, C H Davies, I T Forbes, V A H Fry, J J Hagan, H J Herdon, G A Jones, R Jeggo, J N C Kew, A Mazzali, R Melarange, N Patel, J Pardoe, A D Randall, C Roberts, A Roopun, K R Starr, A Teriakidis, M D Wood, M Whittington, Z Wu, and J Watson (2008). "Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1". Br J Pharmacol 154 (5): 1104–1115. doi:10.1038/bjp.2008.152. PMC 2451039. PMID 18454168.