|Jmol-3D images||Image 1|
|Molar mass||328.49 g mol−1|
| (what is: / ?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
77-LH-28-1 is a recently discovered selective agonist of muscarinic acetylcholine receptor subtype 1 (M1). It is an allosteric agonist, exhibiting over 100-fold specificity for M1 over other muscarinic receptor subtypes. 77-LH-28-1 penetrates the brain by crossing the blood brain barrier and is therefore a useful pharmocologic tool with cognition enhancing effects.
- C J Langmead, N E Austin, C L Branch, J T Brown, K A Buchanan, C H Davies, I T Forbes, V A H Fry, J J Hagan, H J Herdon, G A Jones, R Jeggo, J N C Kew, A Mazzali, R Melarange, N Patel, J Pardoe, A D Randall, C Roberts, A Roopun, K R Starr, A Teriakidis, M D Wood, M Whittington, Z Wu, and J Watson (2008). "Characterization of a CNS penetrant, selective M1 muscarinic receptor agonist, 77-LH-28-1". Br J Pharmacol. 154 (5): 1104–1115. doi:10.1038/bjp.2008.152. PMC 2451039. PMID 18454168.
|This drug article relating to the nervous system is a stub. You can help Wikipedia by expanding it.|