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A-412,997 is a drug which acts as a dopamine agonist that is used in scientific research. It is the first drug developed that is a highly selective agonist for the D4 subtype, with significantly improved selectivity over older D4-preferring compounds such as PD-168,077 and CP-226,269. In animal tests it improved cognitive performance in rats to a similar extent as methylphenidate, but without producing place preference or other signs of abuse liability. Also unlike other dopamine agonists, selective D4 agonists do not cause side effects such as sedation and nausea, and so might have advantages over older dopamine agonist drugs.
- Moreland, RB; Patel, M; Hsieh, GC; Wetter, JM; Marsh, K; Brioni, JD (2005). "A-412997 is a selective dopamine D4 receptor agonist in rats". Pharmacology, Biochemistry, and Behavior 82 (1): 140–7. doi:10.1016/j.pbb.2005.08.001. PMID 16153699.
- Browman, KE; Curzon, P; Pan, JB; Molesky, AL; Komater, VA; Decker, MW; Brioni, JD; Moreland, RB; Fox, GB (2005). "A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats". Pharmacology, Biochemistry, and Behavior 82 (1): 148–55. doi:10.1016/j.pbb.2005.08.002. PMID 16154186.
- Woolley, Marie L.; Waters, Kerry A.; Reavill, Charlie; Bull, Sharlene; Lacroix, Laurent P.; Martyn, Abbe J.; Hutcheson, Daniel M.; Valerio, Enzo; Bate, Simon; Jones, Declan N.C.; Dawson, Lee A. (December 2008). "Selective dopamine D4 receptor agonist (A-412997) improves cognitive performance and stimulates motor activity without influencing reward-related behaviour in rat". Behavioural Pharmacology 19 (8): 765–76. doi:10.1097/FBP.0b013e32831c3b06. PMID 19020411.
- Osinski, MA; Uchic, ME; Seifert, T; Shaughnessy, TK; Miller, LN; Nakane, M; Cox, BF; Brioni, JD; Moreland, RB (2005). "Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets". Pharmacology, Biochemistry, and Behavior 81 (1): 211–9. doi:10.1016/j.pbb.2005.03.012. PMID 15894081.
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