Founded in 1951 and refounded in 1967, Mezzocorona played in the amateur ties of Italian football until 2007, after finishing first in the Girone C during the Serie D 2006-07, thus winning promotion for the first time ever to Serie C2, the fourth tier of Italian football. As one of the nine promoted teams from Serie D, Mezzocorona also participated in the Scudetto Dilettanti tournament but was eliminated in the group stage.
In the Serie C2 2007-08 regular season, Mezzocorona finished a surprising fifth in Girone A, and qualified for the promotional playoffs. The team upset second-placed Carpenedolo in the semi-finals, winning 2–1 on aggregate. In the finals, the team lost to fourth-placed Lumezzane due to the fact it was the lower classified team after the pair ended in a 0–0 aggregate tie, thus remaining in the, now called, Lega Pro Seconda Divisione.