The club was founded in 1962 and in the following years alternating between the D series championships, Eccellenza and Promozione.
Then in 2000-2001 came yet another qualification to Serie D in these years, when the team reached the final of Coppa Italia Serie D, losing to Pievigina.
In 2006-2007 Grottaglie for the first time in its history got into the qualifying play-offs for promotion, but it lost the first game to another team from Apulia, ASD Barletta. The following season, it moved up to 5th place in the league, and again gained qualification for the playoffs, although the race ended at this juncture in the first round against ASD Barletta.
At the end of the 2008-2009 season the team was ranked at 15th and had to go into a relegation play-off against Bitonto. On June 7, 2009, Grottaglie lost 1-0 in an away match at Bitonto, after drawing 0-0 in the first leg, and moved back down to Eccellenza. However, on September 2, 2009, Grottaglie returned to Serie D after the decision of the National Court of Arbitration for Sport to reassign the places in the league. In season 2013-14 Grottaglie play the Serie D Group H, and it arrived at 16th but won the relegation play-off and thus remained in Serie D.