The club was founded in 1962 and in the following years alternating between the D series championships, Eccellenza and Promozione.
Then in 2000-2001 is yet another qualification to Serie D, in these years, the team has reached the final of Coppa Italia Serie D, losing to Pievigina.
In 2006-2007 Grottaglie for the first time in its history centers the qualifying play-offs but lost the first game to another team from Puglia, the ASD Barletta. The following season, came to 5th place in the league, and gained qualification again for the playoffs, even the race ends at this juncture in the first round against the ASD Barletta.
In 2008-2009, the team is ranked 15th place and qualified in the play-out with Bitonto. On June 7, 2009, Grottaglie, lost 1-0 in Bitonto, after a draw in the first leg (0-0), and it returned to Eccellenza. On September 2, 2009, Grottaglie, however, is found again in Serie D after the decision of the National Court of Arbitration for Sport to repechage in the league.