The club, founded in 1932 as S.S. Manfredonia Calcio.. Manfredonia is known for having been the first Italian professional team to play its home matches on a syntheticfootball field.
Manfredonia returned to play in the pros only in 2004, following 64 years of absence from Serie C. In 2004–05 Manfredonia won promotion from Serie C2 to Serie C1, but finished last in its division in 2007–08 and was directly relegated back down to C2, now called Lega Pro Seconda Divisione. At the end of the 2009-2010 season, the company had major financial problems that led the team to failure.
The team was refounded in the summer of 2010 as A.S.D. Manfredonia Football 1932 and began the season in the Eccellenza Apulia. The following year the club was renamed with its current name of A.S.D. Manfredonia Calcio 1932.