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Alpha 1,4-galactosyltransferase
Symbols A4GALT ; A14GALT; A4GALT1; Gb3S; P(k); P1; P1PK; PK
External IDs OMIM607922 MGI3512453 HomoloGene9690 GeneCards: A4GALT Gene
EC number
RNA expression pattern
PBB GE A4GALT 219488 at tn.png
More reference expression data
Species Human Mouse
Entrez 53947 239559
Ensembl ENSG00000128274 ENSMUSG00000047878
UniProt Q9NPC4 Q67BJ4
RefSeq (mRNA) NM_017436 NM_001004150
RefSeq (protein) NP_059132 NP_001004150
Location (UCSC) Chr 22:
43.09 – 43.12 Mb
Chr 15:
83.23 – 83.25 Mb
PubMed search [1] [2]

Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.[1][2]

The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.[2]


  1. ^ Keusch JJ, Manzella SM, Nyame KA, Cummings RD, Baenziger JU (Sep 2000). "Cloning of Gb3 synthase, the key enzyme in globo-series glycosphingolipid synthesis, predicts a family of alpha 1, 4-glycosyltransferases conserved in plants, insects, and mammals.". J Biol Chem 275 (33): 25315–21. doi:10.1074/jbc.M002630200. PMID 10854428. 
  2. ^ a b "Entrez Gene: A4GALT alpha 1,4-galactosyltransferase (globotriaosylceramide synthase)". 

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