Aralkylamine N-acetyltransferase is an enzyme in that humans is encoded by the AANAT gene.
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation.
This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.